Effects of Aloe Vera Toothpaste on Periodontal Parameters

Not Applicable

Completed

• Conditions: Gingivitis
• Interventions: Other: Foramen Herbal Aloe toothpaste; Other: fluoride toothpaste

• Registration Number: NCT02235532
• Lead Sponsor: Islamic Azad University, Tehran

Brief Summary

This study aimed to assess the effects of Aloe Vera toothpaste on dental plaque and gingivitis.

The single-blind cross-over clinical trial was conducted on 20 dental students (10 males and 10 females with a mean age of 24.5±4 yrs.) with gingivitis. Students were randomly divided into 2 groups. The first group used Aloe Vera toothpaste for 30 days. A 2-week wash-out period was allowed and then subjects used fluoride toothpaste for the next 30 days . This order was reversed in group 2.

Detailed Description

Toothpastes are used with tooth brushing to better control microbial plaque. Herbal toothpastes have recently gained attention. This study aimed to assess the effects of Aloe Vera toothpaste on dental plaque and gingivitis.

This single-blind cross-over clinical trial was conducted on 20 dental students (10 males and 10 females with a mean age of 24.5±4 yrs.) with gingivitis. Students were randomly divided into 2 groups. The first group used Aloe Vera toothpaste for 30 days and then their plaque index (PI) and gingival index (GI) were recorded. A 2-week wash-out period was allowed and then subjects used fluoride toothpaste for the next 30 days and underwent PI and GI assessment again. This order was reversed in group 2. Wilcoxon-Sign Rank and two way Repeated Measure ANOVA tests were applied for statistical analysis.

Study Timeline

• Study Start: 2013-09
• Primary Completion: 2014-02
• Study Completion: 2014-06
• Study First Submitted: 2014-08-30
• Study First Submitted QC: 2014-09-09
• Study First Posted: 2014-09-10
• Status Verified: 2015-01
• Last Update Submitted: 2015-01-13
• Last Update Posted: 2015-01-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Subjects were selected among dental students with at least 20 natural teeth without systemic disease
• No periodontal treatment at least 6 months to the study
• No use of systemic antibiotic and anti-inflammatory drugs within the last 3 months, nonsmokers, no pregnancy or lactating women
• Subjects with PD≤3mm, (clinical attachment level)CAL<1mm, PI≥2 and gingival bleeding in more than 30% of the tested areas were enrolled with the diagnosis of plaque-related gingivitis.

Exclusion Criteria

• Subjects with orthodontic appliances ,multiple bridges, partial denture, multiple caries were excluded from the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Foramen Herbal Aloe toothpaste	Foramen Herbal Aloe toothpaste	test group was asked to brush the teeth with Foramen Herbal Aloe toothpaste for 30 days once a day.
use of fluoride toothpaste (signal)	fluoride toothpaste	use of a fluoride toothpaste (signal) in control group once a day for 30 days .

Primary Outcome Measures

Name	Time	Method
measuring gingival index	1-2days	to compare the efficacy of the aloe-vera toothpaste with a known conventional toothpaste, the gingival index was recorded at baseline and after 30 days of consumption and compared with the two understudy toothpastes.

Secondary Outcome Measures

Name	Time	Method
measuring gingival index	1-2 days	to compare the efficacy of the aloe-vera toothpaste with a known conventional toothpaste, the gingival index was recorded at baseline and after 30 days of consumption and compared with the two understudy toothpastes.
measuring plaque index	1-2 days	to compare the efficacy of the aloe-vera toothpaste with a known conventional toothpaste, the plaque index was recorded at baseline and after 30 days of consumption and compared with the two understudy toothpastes.

Trial Locations

Locations (1)

Tehran Dental Branch, Islamic azad University; 🇮🇷 Tehran, Iran, Islamic Republic of