Expression of EPK in Recurrent Miscarriage
Completed
- Conditions
- Recurrent Miscarriage
- Interventions
- Other: Investigate the MAP kinase signaling pathways through ERK and p-ERK proteins
- Registration Number
- NCT02694367
- Lead Sponsor
- Assiut University
- Brief Summary
The present study is based on hypotheses that some as yet unknown genetic factors may result in recurrent miscarriage (RM). Consequently, the main aim of this study was to gain new information about the underlying genetic causes of RM in the Egyptian population and to investigate the expression of ERK and p-ERK protein in human placenta and their corresponding tissue, to assess the significance of MAPK signal pathway in progression of recurrent miscarriage and PI3K-Akt Pathway.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 39
Inclusion Criteria
- Gestational age less than 12 weeks.
- no uterine abnormalities (examined by ultrasonography or hysterosonogram)
- previous history of RM, defined as two or more consecutive miscarriages
Exclusion Criteria
- Gestational age 12 weeks or more.
- Endocrine etiology like (thyroid dysfunction, and uncontrolled diabetes mellitus).
- Antiphospholipid syndrome, inherited thrombophilias, alloimmune causes.
- Uterine anatomic anomalies
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Control group Investigate the MAP kinase signaling pathways through ERK and p-ERK proteins Women with no history of RM Recurrent miscarriage group Investigate the MAP kinase signaling pathways through ERK and p-ERK proteins Women with previous history of RM, defined as two or more consecutive miscarriages
- Primary Outcome Measures
Name Time Method The levels of ERK and AKT in placenta 48 hours
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Ahmed Abbas
🇪🇬Assiut, Cairo, Egypt