Expression of EPK in Recurrent Miscarriage

Completed

• Conditions: Recurrent Miscarriage

• Registration Number: NCT02694367
• Lead Sponsor: Assiut University

Brief Summary

The present study is based on hypotheses that some as yet unknown genetic factors may result in recurrent miscarriage (RM). Consequently, the main aim of this study was to gain new information about the underlying genetic causes of RM in the Egyptian population and to investigate the expression of ERK and p-ERK protein in human placenta and their corresponding tissue, to assess the significance of MAPK signal pathway in progression of recurrent miscarriage and PI3K-Akt Pathway.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-01
• Primary Completion: 2015-12
• Study Completion: 2016-01
• Status Verified: 2016-02
• Study First Submitted: 2016-02-24
• Study First Submitted QC: 2016-02-26
• Last Update Submitted: 2016-02-26
• Study First Posted: 2016-02-29
• Last Update Posted: 2016-02-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 39

Inclusion Criteria

1. Gestational age less than 12 weeks.
2. no uterine abnormalities (examined by ultrasonography or hysterosonogram)
3. previous history of RM, defined as two or more consecutive miscarriages

Exclusion Criteria

1. Gestational age 12 weeks or more.
2. Endocrine etiology like (thyroid dysfunction, and uncontrolled diabetes mellitus).
3. Antiphospholipid syndrome, inherited thrombophilias, alloimmune causes.
4. Uterine anatomic anomalies

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The levels of ERK and AKT in placenta	48 hours

Trial Locations

Locations (1)

Ahmed Abbas; 🇪🇬 Assiut, Cairo, Egypt