Acute Effects of Propylene Glycol/Glycerol Intake on Cardiorespiratory Blood Parameters
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- Cardiorespiratory biological variables
Study Overview
Brief Summary
The aim of this study is to evaluate the acute effect of propylene glycol and glycerol intake on cardiorespiratory blood parameters.
Detailed Description
Background : Propylene glycol/glycerol intake is increasingly popular. Acute effect of propylene glycol and glycerol intake on cardiorespiratory blood parameters is unknown. The investigators postulate that intake of propylene glycol and glycerol could modifiy cardiorespiratory blood parameters.
Aims of this study : to test the following hypotheses :
- Acute intake of propylene glycol and glycerol modifies cardiorespiratory blood parameters.
To test this hypothesis, we will perform blood samples before and after intake of propylene glycol and glycerol. Participants will be tobacco smoker between 18 and 70 years old, with multiple cardiovascular risk factors, and who will undergo a cardiac catherization. After the cardiac catherization, the catheter will be used to perform serial blood samples.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Subject undergoing cardiac catherization
- •Subject must be an active tobacco smoker
Exclusion Criteria
- •Symptoms of infection or inflammation
- •Acute disease including heart rhythm disorder, acute coronary syndrome or decompensation of a chronic disease (heart failure, COPD,...)
- •Unexpected and undesirable effects during the cardiac catherization procedure
- •Respiratory failure requiring supplementary oxygen
Arms & Interventions
Propylene glycol and Glycerol intake
One gram intake of a Propylene glycol/Glycerol mix (50:50)
Intervention: Propylene glycol and Glycerol intake (Other)
Mimicking intake
Mimicking Propylene glycol/Glycerol intake with the device turns off
Intervention: Mimicking intake (Device)
Outcomes
Primary Outcomes
Cardiorespiratory biological variables
Time Frame: 5 minutes
Blood sample
Secondary Outcomes
- Cardiorespiratory biological variables(20 minutes)
Investigators
Martin Chaumont
MD, Cardiology Fellow
Université Libre de Bruxelles