Marginal Periosteal Pedicle Flap - Platelet Rich Fibrin Barriers in Treating Periodontal Intrabony Defects

Phase 2

Completed

• Conditions: Periodontal Pocket
• Interventions: Procedure: Regenerative therapy

• Registration Number: NCT02359539
• Lead Sponsor: Al-Azhar University

Brief Summary

The use of autogenous graft materials has been recorded to be a gold standard in regenerative therapy. This study directed toward evaluation of two autogenous regenerative materials, marginal periosteal pedicle graft (MPP) and platelet rich fibrin (PRF) as membrane barriers for treating intrabony defects. In spite of its reported significant clinical outcomes, the limited availability of the periosteum makes it necessary to evaluate other autogenous alternatives such as PRF that could offer predictable outcomes.

Detailed Description

Material and methods: 10 patients with sever chronic periodontitis and at least single ≥4 mm intrabony defect had participated in this randomized clinical study. Subjects were randomly divided into2 groups, Group 1(MPP) defect coverage with xenograft defect fill(10 patients),Group 2(PRF) defect coverage with xenograft defect fill(10 patients).Clinical and radiographic measurements were carried out at 3,6 and 9 months postoperatively.

Study Timeline

• Study Start: 2009-08
• Primary Completion: 2012-04
• Study Completion: 2013-05
• Status Verified: 2014-11
• Study First Submitted: 2014-11-16
• Study First Submitted QC: 2015-02-09
• Last Update Submitted: 2015-02-09
• Study First Posted: 2015-02-10
• Last Update Posted: 2015-02-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• No systemic diseases that could influence the outcome of therapy
• Good compliance for plaque control instructions after initial therapy
• Vital teeth
• Had contralateral matched pair of 2- or 3-walled intrabony interproximal defects in premolar or molar teeth
• Probing pocket depth (PPD)≥6 mm and clinical attachment level (CAL) ≥4mm 6) selected 2- or 3-wall intrabony defect depth ≥ 3 mm as detected in diagnostic periapical radiographs,

Exclusion Criteria

• Pregnant females and patients presented with opened interproximal contact

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
MPP	Regenerative therapy	Marginal periosteal pedicle
PRF	Regenerative therapy	Platelets rich fibrin,

Primary Outcome Measures

Name	Time	Method
Intrabony defect	9 month after surgery	measurements of intrabony gain from CEJ to base of defect