Does Vestibular Rehabilitation Significantly Improve the Level of Vestibular Function Following Vestibular Neuritis?

Not Applicable

Completed

• Conditions: Vestibular Neuritis
• Interventions: Drug: Corticosteroid; Other: Vestibular rehabilitation

• Registration Number: NCT03821155
• Lead Sponsor: Aalborg University Hospital

Brief Summary

To investigate which treatment option (corticosteroid treatment alone or combined corticosteroid treatment and vestibular rehabilitation) is the most effective in patients diagnosed with vestibular neuritis.

Detailed Description

Patients diagnosed with vestibular neuritis will we consider for enrollment. Each patient will undergo randomization for a specific treatment.

Study Timeline

• Study First Submitted: 2019-01-21
• Study First Submitted QC: 2019-01-27
• Study First Posted: 2019-01-29
• Study Start: 2019-02-01
• Primary Completion: 2021-07-01
• Study Completion: 2022-01-01
• Status Verified: 2022-07
• Last Update Submitted: 2022-07-28
• Last Update Posted: 2022-07-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Age above 18 years of age
2. Medical history compatible with vestibular neuritis
3. Verification of vestibular neuritis with positive romberg test, pathological v-HIT and horizontal nystagmus with a rotatory component.

Exclusion Criteria

1. Former medical history with vestibular dysfunction
2. Medical history or objective signs of cochlear dysfunction before, during or after onset of vestibular neuritis
3. Onset of symptoms 14 days before recruitment to the study
4. Focal neurological symptoms/signs
5. Contraindication to prednisolone treatment
6. Problem with participating in vestibular rehabilitation due to muscular-skeletal disease ect.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Neuritis vestibularis (group 1)	Corticosteroid	Corticosteroid ("prednisolone")
Neuritis vestibularis (group 2)	Corticosteroid	Corticosteroid ("prednisolone") + vestibular rehabilitation
Neuritis vestibularis (group 2)	Vestibular rehabilitation	Corticosteroid ("prednisolone") + vestibular rehabilitation

Primary Outcome Measures

Name	Time	Method
Suppressing head impulse paradigm (SHIMP)	6 month	SHIMP equipment will objectively quantify change of vestibular function.
Subjective visual vertical (SVV)	6 month	SVV test will objectively quantify the experienced spatial orientation as an indicator of visual and vestibular otolithic function
Video head impulse test (v-HIT)	6 month	v-HIT equipment will objectively quantify change of vestibular function.
Dizziness handicap inventory (DHI) questionnaire	6 month	Fulfillment of the questionnaire "Dizziness Handicap Inventory" (DHI) will quantify the level of experienced vertigo.

Trial Locations

Locations (1)

Department of Otolaryngology, Head & Neck Surgery and Audiology; 🇩🇰 Aalborg, North Denmark Region, Denmark