Effect of vitamin E, vitamin D on treatment of infertility in PCOS patients

Phase 2

• Conditions: Condition 1: Polycystic ovarian syndrome. Condition 2: Infertility.; Sclerocystic ovary syndromeStein-Leventhal syndrome; In vitro fertilization

• Registration Number: IRCT2014081018662N1
• Lead Sponsor: Avicenna Infertility Clinic

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

PCOS patients based on ROTERDOM criteria; age:18-38 years old; day3 FSH level less than 12; BMI:20-34.
Exclusion criteria: patients with heart, liver or renal disease; patients with Endometriosis; use of anticoagulats: ASA, Heparin, Warfarin; use of antidepresants:Fluoxetin, Certeralin; use of Statins: Levastatin, Atorvastatin; patients with Eye disease: Retinitis pigmentosa; use of anti inflammatory drugs and corticosteroids:prednisolon; use of vitamins and anti oxidants in 3 months ago; vit K deficiency and bleeding disorders; history of chemotherapy or radiotherapy

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum malondealdehyde. Timepoint: before intervention and after intervention on the oocyte collection day. Method of measurement: American key man kit.;Serum total antioxidant capaity(TAC). Timepoint: before intervention and after intervention on the oocyte collection day. Method of measurement: American key man kit.;Serum super oxid dismuthase. Timepoint: before intervention and after intervention on the oocyte collection day. Method of measurement: American key man kit.;Follicular fluid malondealdehyde. Timepoint: on the oocyte collection day. Method of measurement: American key man kit.;Follicular fluid total anti oxidant capacity. Timepoint: on the oocyte collection day. Method of measurement: American key man kit.;Follicular fluid super oxid dismuthase. Timepoint: on the oocyte collection day. Method of measurement: American key man kit.

Secondary Outcome Measures

Name	Time	Method
Oocyte quality. Timepoint: on the day of oocyte collection. Method of measurement: morphologic assesment with microscope.;ICSI outcome. Timepoint: 2 weeks after embryo transfer. Method of measurement: serum BHCG.