GLOBAL Clinical Study
- Conditions
- Coronary Artery Disease
- Registration Number
- NCT01738828
- Lead Sponsor
- Global Genomics Group, LLC
- Brief Summary
The GLOBAL study is an international multi-center, prospective study designed to enroll up to 10,000 consecutive eligible subjects who are clinically referred for coronary CT angiography for assessment of suspected coronary artery disease (CAD).
The purpose of the study is to perform extensive biomarker analysis of atherosclerosis in patients phenotyped using advanced imaging modalities of atherosclerosis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 10000
- Ages 18-90
- Caucasian and of Non-Hispanic or Non-Latino origin
- Referral for coronary CT angiography to evaluate for presence of CAD
- The patient has signed the appropriate Institutional Review Board approved Informed Consent Form
- Immunosuppressive or immunomodulatory therapy including any dose of systemic corticosteroids in the preceding 30 days (except if steroids are administered as pre-medication prior to contrast administration for CT scan within 24 hours).
- Chemotherapy in the preceding year
- Major surgery in the preceding 2 months
- Blood or blood product transfusion in the preceding 2 months
- Subjects for whom coronary CT angiography is contraindicated per institutional standard of care
- Subjects with previous coronary arterial revascularization (PCI or CABG)
- Subjects with atrial fibrillation/flutter or frequent irregular or rapid heart rhythms, which occurred within the past 3 months
- Subjects with a pacemaker or implantable cardioverter-defibrillator implant
- Active congestive heart failure or the presence of known non-ischemic cardiomyopathy
- Known genetic disorders of atherosclerosis, lipid or lipoprotein metabolism
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Genome-Wide Association Baseline The primary analysis will be a genome-wide association analysis, to determine candidate genes and markers underlying coronary artery disease.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (48)
Zwanger Pesiri Radiology
🇺🇸Stony Brook, New York, United States
Cardiac Study Center
🇺🇸Puyallup, Washington, United States
William Beaumont Hospital
🇺🇸Royal Oak, Michigan, United States
Ohio Health Research Institute
🇺🇸Columbus, Ohio, United States
Allegheny Singer Research Institute
🇺🇸Pittsburgh, Pennsylvania, United States
University of Chicago
🇺🇸Chicago, Illinois, United States
Minneapolis Heart Institute Foundation
🇺🇸Minneapolis, Minnesota, United States
University of Minnesota
🇺🇸Minneapolis, Minnesota, United States
Sentral Clinical Research Services
🇺🇸Cincinnati, Ohio, United States
The Linder Center for Research & Education at The Christ Hospital
🇺🇸Cincinnati, Ohio, United States
University of Cincinnati Physicians Company
🇺🇸Cincinnati, Ohio, United States
Heart Center Research
🇺🇸Huntsville, Alabama, United States
Sutter Roseville Medical Center
🇺🇸Roseville, California, United States
Georgia Regents University
🇺🇸Augusta, Georgia, United States
Poliklinika Sunce
🇭🇷Zagreb, Croatia
The University of Arizona
🇺🇸Tucson, Arizona, United States
Colorado Health Medical Group
🇺🇸Colorado Springs, Colorado, United States
University of Virginia
🇺🇸Charlottesville, Virginia, United States
Baton Rouge General Medical Center
🇺🇸Baton Rouge, Louisiana, United States
United Heart and Vascular Center
🇺🇸St. Paul, Minnesota, United States
Iowa Heart Center
🇺🇸West Des Moines, Iowa, United States
Liverpool Heart and Chest Hospital
🇬🇧Liverpool, United Kingdom
Berks Cardiologists
🇺🇸Wyomissing, Pennsylvania, United States
Greenslopes Private Hospital
🇦🇺Greenslopes, Queensland, Australia
Alfred Hospital
🇦🇺Melbourne, Victoria, Australia
Royal North Shore Hospital
🇦🇺St. Leonards, New South Wales, Australia
The MedStar Heart Research Institute
🇺🇸Washington, District of Columbia, United States
Elite Research and Clinical Trials
🇺🇸Miami Beach, Florida, United States
Long Island Heart Associates
🇺🇸Mineloa, New York, United States
Meander Medical Center
🇳🇱Amersfoot, Netherlands
Detroit Clinical Research Center
🇺🇸Farmington Hills, Michigan, United States
Walter Reed National Military Medical Center
🇺🇸Bethesda, Maryland, United States
Isar Heart Center
🇩🇪Munich, Germany
Canisius Wilhelmina Ziekenhuis
🇳🇱Nijmegen, Netherlands
Institute of Cardiology
🇵🇱Warsaw, Poland
Plymouth Hospitals NHS Trust of Derriford Hospital
🇬🇧Plymouth, United Kingdom
Semmelweis University
🇭🇺Budapest, Hungary
University of Erlangen
🇩🇪Erlangen, Germany
University of Kaposvar
🇭🇺Kaposvar, Hungary
Ulster Hospital
🇬🇧Belfast, United Kingdom
Monash Heart
🇦🇺Clayton, Victoria, Australia
Saint Luke's Lipid and Diabetes Research Center
🇺🇸Kansas City, Missouri, United States
The Prince Charles Hospital
🇦🇺Chermside, Queensland, Australia
St. Francis Hospital
🇺🇸Roslyn, New York, United States
Midwest Heart and Vascular Specialists
🇺🇸Kansas City, Missouri, United States
St. Vincent's Hospital
🇦🇺Darlinghurst, New South Wales, Australia
The University of British Columbia
🇨🇦Vancouver, British Columbia, Canada
Royal Liverpool University Hospital
🇬🇧Liverpool, United Kingdom