Effect of vitamin B1on septic shock patiens

Phase 3

Recruiting

• Conditions: Septic shock.; Severe sepsis with septic shock; R65.21

• Registration Number: IRCT20190602043787N2
• Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 13 July 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

Ages over 18 years old
Patients with septic shock(a patient that meets the criteria for sepsis and despite adequite fluid thrapy needs vasopressor to preserve MAP = 65mmhg and serum lactate is greater than 2 mmol)
Complete informed consent form in the first stage of legal guardianship and in case of failure we refer to the judge of the country
Serum lactate is greater than 2 mmol/li
Hypotention(systolic BP less than 90 mmhg despite adequite fluid thrapy needs vasopressor(Dopamin = 5mcg/kg/min or Phenylephrine)
Refusal to participate in any other intervention research project

Exclusion Criteria

Liver failure or dysfunction(AST OR ALT >240 unit/li or known cirrhosis) based on previous findings that patients with liver dysfunction may have increased levels of thiamine.
Indication of receiving thiamine(Alcohol abuse)
Other causes of increased lactate levels(seizure in 3 hours)
Prescription of high-levev lactate -like drugs (Linezolid-Methformine)by your phicision
Cyanide or CO poisoning
Known mitochondrial disease
Known or suspected ischemia of the intestine or other organs

Study & Design

• Study Type: interventional
• Study Design: Not specified