IRCT20190602043787N2招募中3 期
Effectiveness of initial administration of thiamine in patients with septic shock in patients admitted in the adult intensive care unit
适应症
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 入组人数
- 70
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 no limit（—）
- 性别
- All
入选标准
- •Ages over 18 years old
- •Patients with septic shock(a patient that meets the criteria for sepsis and despite adequite fluid thrapy needs vasopressor to preserve MAP = 65mmhg and serum lactate is greater than 2 mmol)
- •Complete informed consent form in the first stage of legal guardianship and in case of failure we refer to the judge of the country
- •Serum lactate is greater than 2 mmol/li
- •Hypotention(systolic BP less than 90 mmhg despite adequite fluid thrapy needs vasopressor(Dopamin = 5mcg/kg/min or Phenylephrine)
- •Refusal to participate in any other intervention research project
排除标准
- •Liver failure or dysfunction(AST OR ALT >240 unit/li or known cirrhosis) based on previous findings that patients with liver dysfunction may have increased levels of thiamine.
- •Indication of receiving thiamine(Alcohol abuse)
- •Other causes of increased lactate levels(seizure in 3 hours)
- •Prescription of high-levev lactate -like drugs (Linezolid-Methformine)by your phicision
- •Cyanide or CO poisoning
- •Known mitochondrial disease
- •Known or suspected ischemia of the intestine or other organs
研究者
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