NCT01801540已完成不适用
The Effects of L-arabinose in a Meal on Glucose Metabolism in Healthy Men
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 17
- 主要终点
- Glucose
研究概览
简要总结
The purpose of this study is to investigate the effect of a meal containing different doses of L-arabinose, on the intestinal sucrase activity after intake We measure this by measuring the glucose, insulin and c-peptide after meals. Other measurements are made (glucagon and GLP-1) to explain the correlations.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy male
- •normal weight (BMI 18,5-25 kg/m2)
- •18-30 years of age
排除标准
- •Not healthy,including those with diabetes Mellitus, high bloodpressure, dyslipidemia or a infectious diseases (hepatitis or HIV), gastrointestinal disorders
- •Central adipositas (defined as waist circumference > 94 cm for european men)
- •Daily intake of vitamins and minerals, 3 months before the trail starts and during the trail.
- •elevated alcoholcunsumption(> 21 units af alcohol pr. week)
- •take medicine
- •Elite athlete with intensive training
- •given bloddonation within the last 3 months
结局指标
主要结局
Glucose
时间窗: -15, 0, 15, 30, 45, 60, 90, 120, 180 min
Level of glucose over time, The AUC, the peak value and time to peak
Insulin
时间窗: -15, 0, 15, 30, 45, 60, 90, 120, 180 min
Level of insulin over time, the AUC, the peak value and time to peak
C-peptide
时间窗: -15, 0, 15, 30, 45, 60, 90, 120, 180 min
Level of c-peptide over time, The AUC, the peak value and time to peak
次要结局
- Glucagon(-15, 0, 15, 30, 45, 60, 90, 120, 180 min)
- GLP-1(-15, 0, 15, 30, 45, 60, 90, 120, 180 min)
研究者
AAstrup
Dr.Med.Sci./Ph.D.
University of Copenhagen
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