NCT01957098已完成不适用
The Effects of L-Arabinose and D-xylose on Intestinal Sucrase Activity in Man
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Blood glucose, insulin, C-peptide and GLP-1
研究概览
简要总结
The purpose of this study is to investigate the effect of L-arabinose and D-xylose in a sugar-rich drink on intestinal sucrase activity in healthy volunteers by measuring postprandial blood glucose and insulin, and selected intestinal hormonal responses to increasing doses of L-arabinose and D-xylose.
详细描述
Based on previous scientific results we hypotesize, that pentoses decreases the demand for insulin in metabolizing a given dose of sucrose.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy males
- •BMI between 18.4-25 kg/m2
- •age between 18 and 30
排除标准
- •donation of blood 3 months before or during the study
- •gastrointestinal disorders, diabetes, hypertension, hyperlipidemia, chronic infectious disease (HIV or hepatitis)
- •consumption of more than 21 alcoholic drinks/week
- •elite athletes
- •on medication
结局指标
主要结局
Blood glucose, insulin, C-peptide and GLP-1
时间窗: -15, 0, 15, 30, 45, 60, 90, 120, 180 min
Level of glucose, insulin, C-peptide and glucagon-like peptide-1 (GLP-1) over time, the area under the curve (AUC), the peak value and time to peak
次要结局
- Appetite measurements and energy intake(-15, 30, 60, 90, 120, 150 and 180 min)
研究者
AAstrup
Professor
University of Copenhagen
研究点 (2)
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