Minimum effective volume of crystalloid to prevent spinal induced hypotension during elective cesarean delivery: An up-down sequential allocation desig

Phase 2

• Conditions: Healthy pregnancy patients; Pregnancy Coload spinal anesthesia hypotension

• Registration Number: TCTR20201223006
• Lead Sponsor: Faculty of medicine Ramathibodi hospital, Mahidol university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-12-23
• Study Completion: 2021-05-28
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

Singleton term pregnancy
Elective cesarean delivery
American Society of Anesthesiology classification I-II

Exclusion Criteria

History of hypertensive disorder
Gestational age less than 37 weeks
History of cardiovascular disease
History of morbid obesity (Pre-pregnancy BMI > 35 kg/m2)
Height less than 150 cm or more than 190 cm
Inadequate or failed spinal anesthesia
High or total spinal anesthesia

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
volume of crystalloid to prevent spinal hypotension every 2.5 minute until 20 minute after spinal anesthesia milliliter of crystalloid co-loading at time of spinal anesthesia

Secondary Outcome Measures

Name	Time	Method
Cardiac output before, after spinal anesthesia every 2.5 min until 20 minute after spinal block bioimpedance cardiac output measurement,Vassopressor usage end of surgery Total dose of vassopressor after surgery,Baby outcomes after baby delivery 1 and 5 minute apgar score, umbilical artery and venous cord blood gases