Diagnostic Performance of Clinical Signs Patients Suspected of Meningitis to Emergencies

Completed

• Conditions: Meningitis

• Registration Number: NCT02841254
• Lead Sponsor: Nantes University Hospital

Brief Summary

Meningitis are serious infections. Evidenced by high rates of mortality and sequelae. However, these diseases have a relatively small impact. Also physician services Home Emergencies they must be vigilant, alert, for clinical signs to be suspected meningitis. Indeed, it is only after this essential clinical milestone that will be carried out a lumbar puncture which will confirm the diagnosis and to quickly begin treatment.

Unfortunately, if recent studies can improve the therapeutic management of patients with meningitis, no study was interested in yet fundamental step of diagnosis.

It seems therefore necessary to achieve a prospective clinical study to reassess the adequacy of the clinical signs in the diagnosis of meningitis. The ideal would be to achieve a predictive clinical score of the presence or absence of meningitis.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2014-11
• Primary Completion: 2016-05
• Study Completion: 2016-05
• Study First Submitted: 2016-07-19
• Study First Submitted QC: 2016-07-19
• Study First Posted: 2016-07-22
• Status Verified: 2017-08
• Last Update Submitted: 2017-08-09
• Last Update Posted: 2017-08-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 579

Inclusion Criteria

May be included in the study two groups of patients:

*On the one hand, those in which will be carried out a lumbar puncture. Ideally, all patients in whom the examination is envisaged will be included. The logistics must allow inclusion rate as high as possible (see below).

So, are included in this group, patients for which the following criteria are met:

• Over 15 years patient and 3 months,
• Admission to the emergency for less than 6 hours
• Realization of a proposed lumbar puncture,
• Information sheet given. *On the other hand, those in whom it is not intended to be carried by lumbar puncture, but for which the clinical picture present on admission makes relevant for clinical signs of meningitis.

So, are included in this group, patients for which the following criteria are met:

• Over 15 years patient and 3 months,

• Admission to the emergency for less than 6 hours

• At least one of the following 5 clinical signs motivating consultation and / or present on admission:

  • fever (measured temperature above 38 ° C)
  • headache,
  • vomiting,
  • stiff neck,
  • vigilance disorders,

• Information sheet given.

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Exclusion Criteria

• Patient who underwent neurosurgery recent (within the month before admission).

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
meningitis (either viral or bacterial) or absence of meningitis	Until 2 days

Trial Locations

Locations (3)

Nantes University Hospital; 🇫🇷 Nantes, France

Saint-nazaire Hospital; 🇫🇷 Saint-Nazaire, France

Châteaubriant Hospital; 🇫🇷 Châteaubriant, France