Characterization and Differential Diagnosis of Postneurosurgical Meningitis
- Conditions
- Neurosurgery
- Registration Number
- NCT01122537
- Lead Sponsor
- Asan Medical Center
- Brief Summary
Meningitis is a rare complication following neurosurgical procedures and is associated with high morbidity and mortality. The aim of this study is to describe the clinical characteristics and microbiological characteristics in patients who develope meningitis following neurosurgical operations, and investigate the useful tips for the differential diagnosis of postneurosurgical meningitis.
- Detailed Description
Besides description of characteristics of patients with postneurosurgical patients, we also will investigate the usefulness of prolonged cerebrospinal fluid (CSF) culture, and profiles of blood and CSF inflammatory markers for the differential diagnosis of meningitis. CSF culture will be extended upto 2 weeks. Serum procalcitonin and C-reactive protein, CSF adenosine deaminase levels will be monitored and analyzed for the differential diagnosis of meningitis.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 78
- Cerebrospinal fluid corrected WBC >6/mm^3 and/or fever (> 38℃) and/or neck stiffness
- Patients already treated more than 48 hours for meningitis before cerebrospinal fluid examination
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Development of meningitis within 4 weeks after neurosurgical operation
- Secondary Outcome Measures
Name Time Method All-cause mortality within 4 weeks after the diagnosis of meningitis
Trial Locations
- Locations (1)
Asan Medical Center
🇰🇷Seoul, Korea, Republic of