Clinical Features, Microbiological Characteristics, and Differential Diagnosis of Postneurosurgical Meningitis
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Asan Medical Center
- Enrollment
- 78
- Locations
- 1
- Primary Endpoint
- Development of meningitis
Study Overview
Brief Summary
Meningitis is a rare complication following neurosurgical procedures and is associated with high morbidity and mortality. The aim of this study is to describe the clinical characteristics and microbiological characteristics in patients who develope meningitis following neurosurgical operations, and investigate the useful tips for the differential diagnosis of postneurosurgical meningitis.
Detailed Description
Besides description of characteristics of patients with postneurosurgical patients, we also will investigate the usefulness of prolonged cerebrospinal fluid (CSF) culture, and profiles of blood and CSF inflammatory markers for the differential diagnosis of meningitis. CSF culture will be extended upto 2 weeks. Serum procalcitonin and C-reactive protein, CSF adenosine deaminase levels will be monitored and analyzed for the differential diagnosis of meningitis.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 16 Years to — (Child, Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Cerebrospinal fluid corrected WBC >6/mm^3 and/or fever (> 38℃) and/or neck stiffness
Exclusion Criteria
- •Patients already treated more than 48 hours for meningitis before cerebrospinal fluid examination
Outcomes
Primary Outcomes
Development of meningitis
Time Frame: within 4 weeks after neurosurgical operation
Secondary Outcomes
- All-cause mortality(within 4 weeks after the diagnosis of meningitis)
Investigators
Sang-Ho Choi
Doctor
Asan Medical Center