跳至主要内容
临床试验/NCT01122537
NCT01122537已完成不适用

Clinical Features, Microbiological Characteristics, and Differential Diagnosis of Postneurosurgical Meningitis

Asan Medical Center1 个研究点 分布在 1 个国家目标入组 78 人开始时间: 2010年5月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
78
试验地点
1
主要终点
Development of meningitis

研究概览

简要总结

Meningitis is a rare complication following neurosurgical procedures and is associated with high morbidity and mortality. The aim of this study is to describe the clinical characteristics and microbiological characteristics in patients who develope meningitis following neurosurgical operations, and investigate the useful tips for the differential diagnosis of postneurosurgical meningitis.

详细描述

Besides description of characteristics of patients with postneurosurgical patients, we also will investigate the usefulness of prolonged cerebrospinal fluid (CSF) culture, and profiles of blood and CSF inflammatory markers for the differential diagnosis of meningitis. CSF culture will be extended upto 2 weeks. Serum procalcitonin and C-reactive protein, CSF adenosine deaminase levels will be monitored and analyzed for the differential diagnosis of meningitis.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
16 Years 至 —(Child, Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Cerebrospinal fluid corrected WBC >6/mm^3 and/or fever (> 38℃) and/or neck stiffness

排除标准

  • Patients already treated more than 48 hours for meningitis before cerebrospinal fluid examination

结局指标

主要结局

Development of meningitis

时间窗: within 4 weeks after neurosurgical operation

次要结局

  • All-cause mortality(within 4 weeks after the diagnosis of meningitis)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Sang-Ho Choi

Doctor

Asan Medical Center

研究点 (1)

Loading locations...

相似试验