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Early Diagnosis of Intracranial Infection After Craniotomy

Conditions
Intracranial; Infection, Psychosis, Acute or Subacute
Registration Number
NCT04215094
Lead Sponsor
Pan Jun
Brief Summary

Intracranial infection are serious complications postoperatively in neurosurgical patients. Early identification of these complications is essential to minimize the mortality and moribidy. The aim of this study is observe the postoperative dynamic changes of body temperature (BT), procalcitonin (PCT), C-reactive protein (CRP), and white blood cell (WBC) count, and evaluate whether the use of two or more of these markers may improve the diagnostic accuracy of intracranial infection.

Detailed Description

Intracranial infection is a serious complications after neurosurgical operation. Early identification of intracranial infection is important so that, first, optimal treatment is initiated which may improves outcome, second, inappropriate antibiotic treatment and subsequent resistance are prevented, and third, it will promote shorter hospitalization and less cost. In several previous studies, the values of procalcitonin (PCT) and C-reactive protein (CRP) in predicting intracranial infection have been evaluated in neurosurgical patients. However, due to the limited number of studies, the results are not convincing enough and more investigations seems warranted to clarify their dynamic changes in neurosurgical patients without intracranial infection and their role in confirming the suspicion of intracranial infection or excluding intracranial infection from the differential diagnosis.

The aim of the investigator's study is to observe the postoperative dynamic changes of BT, PCT, CRP, and white blood cell (WBC) count, and evaluate whether the use of two or more of these markers may improve the diagnostic accuracy for rational decisions about antibiotic treatment.

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
500
Inclusion Criteria
  1. craniotomy of brain tumor;
  2. no clinical manifestations of infection before operation;
  3. no other infection such as respiratory tract infection, urinary tract infection and deep vein catheter infection before the definite diagnosis of intracranial infection ;
  4. the patients had informed consent to enter the study.
Exclusion Criteria
  1. blood system diseases,respiratory tract infection, urinary tract infection and deep vein catheter infection;
  2. malignant tumors with neuroendocrine characteristicsr;
  3. aspiration, pancreatitis, etc.

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
the diagnosis of intracranial infection after craniotomyup to 100 weeks

Intracranial infection are serious complications postoperatively in neurosurgical patients. Early identification of these complications is essential to minimize the mortality and moribidy. The aim of this study is observe the postoperative dynamic changes of body temperature (BT), procalcitonin (PCT), C-reactive protein (CRP), and white blood cell (WBC) count, and evaluate whether the use of two or more of these markers may improve the diagnostic accuracy of intracranial infection

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Neurosurgery department, Nanfang hospital

🇨🇳

Guangzhou, Guangdong, China

Neurosurgery department, Nanfang hospital
🇨🇳Guangzhou, Guangdong, China
xi'an Zhang, MD, PhD
Contact
48831443@qq.com
Junxiang Peng, MD,PHD
Contact
pjxlaozong@126.com

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