A Novel Myocardial Impedance Mapping System for Ablation of Post-infarction Ventricular Arrhytmias in Humans
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Comparative detection of infarct scar by impedance mapping
研究概览
简要总结
Precise identification of the infarct scar is essential for successful catheter ablation of ventricular arrhythmias in patients with chronic myocardial infarction. Voltage mapping of endocardial electrograms is currently used to delineate the necrotic scar but this is influenced by the direction of the activation wave front and is not sensitive enough to differentiate distinct degrees of transmural injury in the scar. Mapping of local myocardial electrical impedance may overcome these limitations.
详细描述
Clinical series: Patients with chronic infarction undergoing catheter ablation of ventricular arrhythmias will be submitted to mapping of both voltage and tissue impedance. Likewise, the accuracy of the two maps identifying the extent and transmurality of the infarction will be assesssed by gadolinium imaging. The impedance system is already constructed and certified for clinical research use.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •More than 18 yearts
- •Chronic myocardial infarction
- •Undergoing ventricular ablation of ventricular arrhythmias
排除标准
- •patients with device not suitable for cardiac magnetic ressonance (CMR)
结局指标
主要结局
Comparative detection of infarct scar by impedance mapping
时间窗: 3 hours
myocardial local impedance will be measured at different sites of the infarct scar and healthy tissue.
Comparative detection of infarct scar by gadolinium enhanced MR imaging
时间窗: 30 minutes
Intensity of gadolinium will be measured at different sites of the infarct scar and healthy tissue.
Comparative detection of infarct scar by voltage mapping
时间窗: 3 hours
Voltage will be measured at different sites of the infarct scar and healthy tissue.
次要结局
未报告次要终点