A Novel Myocardial Impedance Mapping System for Ablation of Post-infarction Ventricular Arrhytmias in Humans
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Ventricular Arrythmia
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
- Enrollment
- 25
- Locations
- 1
- Primary Endpoint
- Comparative detection of infarct scar by impedance mapping
- Last Updated
- 6 years ago
Overview
Brief Summary
Precise identification of the infarct scar is essential for successful catheter ablation of ventricular arrhythmias in patients with chronic myocardial infarction. Voltage mapping of endocardial electrograms is currently used to delineate the necrotic scar but this is influenced by the direction of the activation wave front and is not sensitive enough to differentiate distinct degrees of transmural injury in the scar. Mapping of local myocardial electrical impedance may overcome these limitations.
Detailed Description
Clinical series: Patients with chronic infarction undergoing catheter ablation of ventricular arrhythmias will be submitted to mapping of both voltage and tissue impedance. Likewise, the accuracy of the two maps identifying the extent and transmurality of the infarction will be assesssed by gadolinium imaging. The impedance system is already constructed and certified for clinical research use.
Investigators
Eligibility Criteria
Inclusion Criteria
- •More than 18 yearts
- •Chronic myocardial infarction
- •Undergoing ventricular ablation of ventricular arrhythmias
Exclusion Criteria
- •patients with device not suitable for cardiac magnetic ressonance (CMR)
Outcomes
Primary Outcomes
Comparative detection of infarct scar by impedance mapping
Time Frame: 3 hours
myocardial local impedance will be measured at different sites of the infarct scar and healthy tissue.
Comparative detection of infarct scar by gadolinium enhanced MR imaging
Time Frame: 30 minutes
Intensity of gadolinium will be measured at different sites of the infarct scar and healthy tissue.
Comparative detection of infarct scar by voltage mapping
Time Frame: 3 hours
Voltage will be measured at different sites of the infarct scar and healthy tissue.