Impact of Netrin-1 in the Pathophysiology of Placenta Accreta Spectrum
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- impact of netrin-1 in the pathophysiology of placenta accreta spectrum
研究概览
简要总结
The main goal of this study the possible involvement of netrin-1 into the pathophysiology of placenta accrete spectrum.
To delineate the role of netrin-1, neogenin - zeb1 signaling pathway in mechanism of morbidly adherent placenta.
详细描述
The main goal of this study is:
- To shed light on the possible involvement of netrin-1 into the pathophysiology of placenta accrete spectrum.
- To study the role of netrin-1 in Epithelial to mesenchymal transition as a possible pathophysiological mechanism of placenta accrete spectrum.
- To delineate the role of netrin-1, neogenin - zeb1 signaling pathway in the progression of invasion of placenta accrete spectrum.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •ages between 20 to 40 years will be included.
- •Gestational age: between 34 to 38 weeks.
- •History of previous cesarean sections. suspected intra-operative abnormal placental adhesion of variable degrees
排除标准
- •Fundal and middle anterior or posterior placenta.
- •Pregnancy associated with morbid conditions as: hypertension, diabetes mellitus, autoimmune disease, cardiac disease, renal disease, and endocrinal disease.
结局指标
主要结局
impact of netrin-1 in the pathophysiology of placenta accreta spectrum
时间窗: baseline
1. Evaluation of the immunohistochemical expression of netrin 1 in PAS specimens in comparison with the control placental tissues. 2. Evaluation of the immunohistochemical expression of neogenin in PAS specimens in comparison with the control placental tissues 3. Evaluation of the immunohistochemical expression of ZEB1 in PAS specimens in comparison with the control placental tissues. 4. Correlate their immunohistochemical expression with the demographic parameters and assess the correlation between their expression in PAS specimens.
次要结局
未报告次要终点
研究者
Hanaa Mohammed Mohammed Sayed
assistant lecturer
Assiut University