Impact of Netrin-1 in the Pathophysiology of Placenta Accreta Spectrum

Completed

• Conditions: Pathophysiology of Placenta Accreta
• Interventions: Other: no intervention applied

• Registration Number: NCT04628169
• Lead Sponsor: Assiut University

Brief Summary

The main goal of this study the possible involvement of netrin-1 into the pathophysiology of placenta accrete spectrum.

To delineate the role of netrin-1, neogenin - zeb1 signaling pathway in mechanism of morbidly adherent placenta.

Detailed Description

The main goal of this study is:

* To shed light on the possible involvement of netrin-1 into the pathophysiology of placenta accrete spectrum.

* To study the role of netrin-1 in Epithelial to mesenchymal transition as a possible pathophysiological mechanism of placenta accrete spectrum.

* To delineate the role of netrin-1, neogenin - zeb1 signaling pathway in the progression of invasion of placenta accrete spectrum.

Study Timeline

• Study First Submitted: 2020-11-09
• Study First Submitted QC: 2020-11-09
• Study First Posted: 2020-11-13
• Study Start: 2021-12-01
• Primary Completion: 2022-11-01
• Study Completion: 2023-12-01
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-12
• Last Update Posted: 2024-05-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

• ages between 20 to 40 years will be included.
• Gestational age: between 34 to 38 weeks.
• History of previous cesarean sections. suspected intra-operative abnormal placental adhesion of variable degrees

Exclusion Criteria

Fundal and middle anterior or posterior placenta.

• Pregnancy associated with morbid conditions as: hypertension, diabetes mellitus, autoimmune disease, cardiac disease, renal disease, and endocrinal disease.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
group A	no intervention applied	30 placental specimens of PAS
group B	no intervention applied	30 placental specimens of heaithy women with normal pregnancy

Primary Outcome Measures

Name	Time	Method
impact of netrin-1 in the pathophysiology of placenta accreta spectrum	baseline	1. Evaluation of the immunohistochemical expression of netrin 1 in PAS specimens in comparison with the control placental tissues.; 2. Evaluation of the immunohistochemical expression of neogenin in PAS specimens in comparison with the control placental tissues; 3. Evaluation of the immunohistochemical expression of ZEB1 in PAS specimens in comparison with the control placental tissues.; 4. Correlate their immunohistochemical expression with the demographic parameters and assess the correlation between their expression in PAS specimens.

Trial Locations

Locations (1)

Hanaa Mohammed Mohammed Sayed; 🇪🇬 Assiut, Egypt