Association Between Peripheral Muscle Function and Quality of Life in Obese Subjects.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- Association between structural alteration of the quadriceps and quality of life in obese patients
研究概览
简要总结
The assessment of health status and physical function is fundamental in patients with obesity, as they play an important role among the various factors influencing the quality of life in this population. Several studies have shown an association between high BMI values and a significant deterioration in quality of life, especially in women. Excess body fat in obese patients seems to be responsible for muscle atrophy. This causal link is probably related to dysfunctions in adipose tissue, leading to a decrease in the expression of proteins responsible for muscle contraction. The recent literature highlights an alteration in quality of life, particularly in obese and elderly subjects, for which changes in muscle function are partly responsible. Changes in muscle function can be assessed by simple, rapid and non-invasive tools. They could be used to identify obese subjects at risk of they could be used to identify obese subjects at risk of muscle atrophy, to stratify the risk, and to propose prophylactic intervention or early management.
The main objective of this study is to evaluate the association between structural alteration of the quadriceps and quality of life in obese patients.
The secondary objectives are to evaluate :
- The association between quadriceps thickness and quality of life ;
- The association between grip strength and quality of life ;
- The association between quadriceps strength and quality of life ;
- The association between quadriceps strength and ultrasound measurements of the quadriceps.
This is a prospective, monocenter, observationnal and cohort study.
All outpatients for nutrition assessment will be included.
详细描述
- Rationale 1.1 Obesity, a global public health Obesity is a disease of multifactorial origin, linked to nutritional alterations, genetic, psychological, socio-economic factors and more sedentary behaviour (4) (5). The prevalence of obesity continues to increase in all age groups and in all socio-economic groups.
1.2 Functional consequences of obesity. Patients with obesity with or without metabolic disorders have impaired health, including mental problems and reduced quality of life (12). In younger obese subjects the investigators also observe a decrease in quality of life compared to normal weight subjects, where muscle capacity may be a potential factor associated with impaired quality of life (13).
1.2.1 Peripheral muscle damage A decrease in the specific force of the muscle, a decrease in force in relation to the sectional area, is observed in subjects with obesity. There is therefore probably a structural alteration of the muscle in the obese patient, which has not yet been described in the literature (17).
1.3 Peripheral muscle ultrasound Muscle ultrasound measurements have become increasingly used as a non-invasive method of determining muscle characteristics (21). Muscle characteristics, particularly muscle size and quality, have been shown to be related to muscle strength and power as well as cardiovascular performance. 2. Research hypothesis The investigators hypothesise that impaired peripheral muscle function is associated with impaired quality of life in obese subjects.
3 Objective 3.1 Main objective The main objective of this study is to evaluate the association between structural alteration of the quadriceps and quality of life in obese patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with the following criteria will be included:
- •Outpatients assessment Nutrition ;
- •Obese patients (BMI > 30);
- •Patient at least 18 years old at the time of inclusion;
- •Affiliation with a social security scheme or beneficiary of such a scheme ;
- •Oral, free, informed and express consent of the patient.
排除标准
- •Patient's refusal to participate in the study ;
- •Known pregnancy ;
- •Patient whose state of consciousness is not compatible with obtaining consent ;
- •Person subject to a legal protection measure ;
- •Patient under guardianship or curatorship
结局指标
主要结局
Association between structural alteration of the quadriceps and quality of life in obese patients
时间窗: Through study completion, an average of 9 months
The main outcome is the association between rectus femoris muscle echogenicity in the gray scale and the 36-Item Short Form Survey (SF-36) score
次要结局
- Association between grip strength and quality of life(Through study completion, an average of 9 months)
- The association between quadriceps thickness and quality of life(Through study completion, an average of 9 months)
- Association between quadriceps strength and ultrasound measurements of the quadriceps(Through study completion, an average of 9 months)
- Association between quadriceps strength and quality of life(Through study completion, an average of 9 months)