The Effect of Weight Loss on Ovarian Reserve
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Anti Mullerain Hormone (AMH)and AFC before and after weight loss
研究概览
简要总结
Obesity affects on fertility. Obese women have lower pregnancy rate after infertility treatments.They need more doses of hormone during ovarian stimulation, more days for stimulation. During IVF treatment less oocytes are collected and the quality of embryo also harmed.
The first line treatment for those women with obesity and infertility is weight loss.
The investigators' hypothesis is that weight reduction improves ovarian reserve and fertility treatment outcome.
详细描述
The investigators have outpatient clinic for obesity and infertility. the patients undergoing program of 3 months with diet and physical activity. Blood sample will take at the beginning of the program and at the end. The blood sample will evaluate for: AMH, Adiponectin, Leptin, CRP, Colesterol, CRP, Smac in addition TVUS will perform to evaluate AFC.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 43 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •undergoing weight loss program
排除标准
- •dropp out before comletion the weighy loss target
结局指标
主要结局
Anti Mullerain Hormone (AMH)and AFC before and after weight loss
时间窗: 3 months
AMH and AFC will measure at the first visit and after 3 months of weight loss program
次要结局
未报告次要终点
研究者
Amir Wiser
Senior physician IVF Unit
Meir Medical Center