The Effect of Weight Loss on Ovarian Reserve

• Conditions: Weight Loss
• Interventions: Dietary Supplement: weight loss

• Registration Number: NCT01844128
• Lead Sponsor: Meir Medical Center

Brief Summary

Obesity affects on fertility. Obese women have lower pregnancy rate after infertility treatments.They need more doses of hormone during ovarian stimulation, more days for stimulation. During IVF treatment less oocytes are collected and the quality of embryo also harmed.

The first line treatment for those women with obesity and infertility is weight loss.

The investigators' hypothesis is that weight reduction improves ovarian reserve and fertility treatment outcome.

Detailed Description

The investigators have outpatient clinic for obesity and infertility. the patients undergoing program of 3 months with diet and physical activity. Blood sample will take at the beginning of the program and at the end. The blood sample will evaluate for: AMH, Adiponectin, Leptin, CRP, Colesterol, CRP, Smac in addition TVUS will perform to evaluate AFC.

Study Timeline

• Status Verified: 2013-04
• Study First Submitted: 2013-04-28
• Study First Submitted QC: 2013-04-30
• Study Start: 2013-05
• Study First Posted: 2013-05-01
• Last Update Submitted: 2013-06-10
• Last Update Posted: 2013-06-11
• Primary Completion: 2014-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

• undergoing weight loss program

Exclusion Criteria

• dropp out before comletion the weighy loss target

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
overweight women with infertility	weight loss	-

Primary Outcome Measures

Name	Time	Method
Anti Mullerain Hormone (AMH)and AFC before and after weight loss	3 months	AMH and AFC will measure at the first visit and after 3 months of weight loss program

Trial Locations

Locations (1)

Meir Medical Center; 🇮🇱 Kfar Sava, Israel