The Effect of Weight Loss on Ovarian Reserve
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Weight Loss
- Sponsor
- Meir Medical Center
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Anti Mullerain Hormone (AMH)and AFC before and after weight loss
- Last Updated
- 12 years ago
Overview
Brief Summary
Obesity affects on fertility. Obese women have lower pregnancy rate after infertility treatments.They need more doses of hormone during ovarian stimulation, more days for stimulation. During IVF treatment less oocytes are collected and the quality of embryo also harmed.
The first line treatment for those women with obesity and infertility is weight loss.
The investigators' hypothesis is that weight reduction improves ovarian reserve and fertility treatment outcome.
Detailed Description
The investigators have outpatient clinic for obesity and infertility. the patients undergoing program of 3 months with diet and physical activity. Blood sample will take at the beginning of the program and at the end. The blood sample will evaluate for: AMH, Adiponectin, Leptin, CRP, Colesterol, CRP, Smac in addition TVUS will perform to evaluate AFC.
Investigators
Amir Wiser
Senior physician IVF Unit
Meir Medical Center
Eligibility Criteria
Inclusion Criteria
- •undergoing weight loss program
Exclusion Criteria
- •dropp out before comletion the weighy loss target
Outcomes
Primary Outcomes
Anti Mullerain Hormone (AMH)and AFC before and after weight loss
Time Frame: 3 months
AMH and AFC will measure at the first visit and after 3 months of weight loss program