Lithium Clearance in Patients With High Risk of Acute Kidney Injury

Completed

• Conditions: Acute Kidney Injury
• Interventions: Diagnostic Test: Lithium measures

• Registration Number: NCT05648435
• Lead Sponsor: University Hospital of North Norway

Brief Summary

Renal lithium clearance is hypothesized to be a useful indicator of renal tubular function.

In this study lithium clearance will be monitored in patients with sepsis associated acute kidney injury and in healthy controls.

Detailed Description

Lithium is almost completely reabsorbed in the proximal tubule in parallel with sodium and water. What is not reabsorbed here is assumed to be fully excreted in urine, giving a reasonably accurate measurement of sodium reabsorption in the proximal tubule. Endogenous lithium clearance will be measured by inductively coupled plasma mass spectrometry (ICP-MS). The Gomez equations will be applied to calculate efferent arteriolar resistance, afferent arteriolar resistance, glomerular hydrostatic pressure, glomerular filtration pressure, and glomerular oncotic pressure. N-acetyl-β-D glucosaminidase (NAG) and NGAL, markers of tubular injury, will be measured by a spectrophotometric method using a commercially available kit. Routine blood and urine analyses will be performed at the Diagnostic Clinic Laboratory, University Hospital of North Norway, Tromsø.

Study Timeline

• Status Verified: 2022-12
• Study First Submitted: 2022-12-05
• Study First Submitted QC: 2022-12-05
• Study Start: 2022-12-07
• Study First Posted: 2022-12-13
• Primary Completion: 2023-01-31
• Study Completion: 2023-01-31
• Last Update Submitted: 2023-04-11
• Last Update Posted: 2023-04-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

Not provided

Exclusion Criteria

Oliguria or renal impairment due to other causes than sepsis. Pregnancy or breast-feeding.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Sepsis patients	Lithium measures	No interventions
Healthy controls	Lithium measures	No interventions

Primary Outcome Measures

Name	Time	Method
Renal lithium clearance	Repeated measures between 07:00-20:00	Measurement of renal lithium clearance at 8AM, 2 PM, and 8 PM

Trial Locations

Locations (1)

University Hospital of North Norway; 🇳🇴 Tromsø, Troms, Norway