Alterations in Connective Tissue in Patients With or Without Pelvic Organ Prolapse
- Conditions
- Pelvic Organ Prolapse
- Registration Number
- NCT01749696
- Lead Sponsor
- Turku University Hospital
- Brief Summary
The aim of our study is to investigate the alterations in connective tissue of vaginal wall in patients with and without pelvic organ prolapse (POP).
- Detailed Description
The tissue samples were taken from the anterior wall of vagina in the midline close to cervix or apex. The tissue samples were collected from the vaginal wall of the patients with pelvic organ prolapse (n=39) during vaginal prolapse surgery. Control samples (n=39) were taken from patients after vaginal or laparoscopic removal of the uterus.
The formalin-fixed and paraffin embedded tissue samples were stained with Verhoeff van Gieson and Movat's pentachrome. Samples were examined by pathologist and gynecologist blinded as to the other investigator and to the pelvic organ prolapse status. In case of discrepancy investigators evaluated the samples together to gain consensus.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 78
- surgery for pelvic organ prolapse
- hysterectomy due to other benign reasons than pelvic organ prolapse
- surgery due to malignancy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The elastin content in tissue samples in patients with or without pelvic organ prolapse. september 2012
- Secondary Outcome Measures
Name Time Method The collagen content in tissue samples in women with or without pelvic organ prolapse. September 2012
Trial Locations
- Locations (1)
Department of Obstetrics and Gynecology, Turku University Central Hospital
🇫🇮Turku, Finland