Low Versus High PEEP in Noninvasive Ventilation for Hypoxemic Respiratory Failure
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Noninvasive Ventilation
- Sponsor
- Chongqing Medical University
- Enrollment
- 380
- Locations
- 1
- Primary Endpoint
- Rate of noninvasive ventilation failure
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
Current study aimed to explore the effect of high PEEP during noninvasive ventilation among hypoxemic patients with acute respiratory failure.
Detailed Description
This was a 1:1 randomized control trial to explore the effect of high versus low PEEP in noninvasive ventilation hypoxemic patients with acute respiratory failure. Several ICUs in China performed this study. In the high PEEP group, the PEEP maintained at 10-15 cmH2O, the inspiratory pressure maintained at 15-20 cmH2O. In the low PEEP group, the PEEP maintained at 5 cmH2O, the inspiratory pressure maintained at 10-20 cmH2O. The primary outcome was incidence of noninvasive ventilation failrue.
Investigators
Duan jun
Principal Investigator
Chongqing Medical University
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Rate of noninvasive ventilation failure
Time Frame: From randomization to 28 days of study
Noninvasive ventilation failure was defined as intubation, death or withdrawal of therapy during noninvasive ventilation.
Secondary Outcomes
- 28-day mortality(From randomization to 28 days of study)
- Length of stay in ICU(From beginning to 28 days of study)
- The changes of PaO2/FiO2(From randomization to 28 days of study)
- Duration of invasive mechanical ventilation(From randomization to 28 days of study)
- Duration of noninvasive ventilation(From beginning to 28 days of study)
- Length of stay in hospital(From beginning to 28 days of study)
- Side effect(From randomization to 28 days of study)