Central Pain Syndrome in Survivors of Head and Neck Cancer

Not Applicable

Terminated

Interventions: Device: IPC-1000
Device: Magnetic resonance imaging
Other: Correlative Studies

Brief Summary: This is a cross-sectional pilot study of head and neck cancer survivors who have completed multi-modal treatment to assess and characterize the presence of distinct pain syndromes.

Detailed Description: Primary objectives:

* To correlate structural and functional MRI signature with one of three pain phenotypes in head and neck cancer survivors: 1) no pain, 2) central pain, and 3) nociceptive pain.

* To correlate the presence of chronic systemic symptoms with pain phenotype

Exploratory objectives:

- DNA, RNA, and plasma will be collected for genomic, transcriptomic, and proteomic studies. Results will be vertically integrated along with the results of clinical studies described within this protocol to identify targets for future correlative studies.

Recruitment & Eligibility

Inclusion Criteria

Patients with histologically proven head and neck cancer
Patients without a diagnosis of head and neck cancer (up to 10 patients, see below)
- We anticipate enrolling a total of 75 patients with a history of head and neck cancer who will complete all questionnaires and MRI scanning. We will also recruit up to 10 patients WITHOUT a diagnosis of head and neck cancer to facilitate optimization of the MRI scanning processes. This will allow us to address logistical issues, such as pressure stimulator setup and timing of each scan to be performed.
Completed multi-modality therapy a minimum of 6 weeks prior to study entry.
Willing and able to provide informed consent
All participants must be at least 21 years of age
Able to speak English

Exclusion Criteria

Patients who are pregnant
Patients who are unable to lie still
Patients who are unable tolerate pressure stimulator
Non-MRI compatible devices such as aneurysm clips, cardiac pacemakers or defibrillators, cochlear implants, hardware, or any other implants
Iron-based tattoos, pieces of metal (bullet, BB, shrapnel) close to or in an important organ (such as the eye), or other non-MRI compatible metal in the body

Arm && Interventions

Group	Intervention	Description
Response to Pain	Correlative Studies	Brain's response to pain using magnetic resonance imaging (MRI)
Response to Pain	IPC-1000	Brain's response to pain using magnetic resonance imaging (MRI)
Response to Pain	Magnetic resonance imaging	Brain's response to pain using magnetic resonance imaging (MRI)

Primary Outcome Measures

Name	Time	Method
Magnetic Resonance Imaging (MRI) to Correlate Presence of Chronic Systemic Symptoms With Pain Phenotype	Approximately 8 weeks	MRI scan of brain to measure response to stimulated pressure to thumbnail
Magnetic Resonance Imaging (MRI) to Correlate With One of Three Pain Phenotypes 1) no Pain, 2) Central Pain, 3) Nociceptive Pain	Approximately 8 weeks	MRI scan of brain to measure response to stimulated pressure to thumbnail

Secondary Outcome Measures