Comparison of the Efficacy of High-Flow Nasal Oxygen Therapy and Noninvasive Ventilation in patients with COPD Exacerbatio

Not Applicable

• Conditions: Chronic obstructive pulmonary disease (COPD).; Chronic obstructive pulmonary disease with (acute) exacerbation; J44.1

• Registration Number: IRCT20160516027929N7
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 15 June 2020

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 68

Inclusion Criteria

The presence of chronic obstructive pulmonary disease (COPD) and acute respiratory failure
pH < 7.35
Arterial pressure of carbon dioxide (PaCO2) equal to or greater than 45mmHg

Exclusion Criteria

- Mechanical ventilation in the past 60 days (using any non-invasive ventilation or high blood oxygen through the nasal cannula (HFNT) prior to enrollment in the study and after the onset of acute upper respiratory failure (AHRF)
- Non-invasive ventilation for home care
- Undesirable clinical condition (require a vasopressor for> 24 hours, acute coronary syndrome or life-threatening arrhythmias (
- Refusal of treatment
- Disorder in more than two organs
-Heart failure
- The respiratory tract requires a tracheal intubation
- Trauma or burn in the neck and face
- Pregnancy
- Refusal of consent
- enter to other research protocols

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
PaCO2. Timepoint: before intervention- one hour after - half hour after- after intervention. Method of measurement: ABG.

Secondary Outcome Measures

Name	Time	Method
SaO2. Timepoint: befor intervention-one hour after-half hour after- after intervention. Method of measurement: ABG.