Catheter-related Bloodstream Infections in Patients With Intestinal Failure Receiving Home Parenteral Support: Risks Related to a Catheter-salvage-strategy.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Intestinal Failure
- Sponsor
- Rigshospitalet, Denmark
- Enrollment
- 715
- Locations
- 1
- Primary Endpoint
- new catheter-related bloodstream infections
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
This is an observational study evaluating a catheter salvage strategy in relation to catheter-related bloodstream infections in patients with chronic intestinal failure dependent on home parenteral support. The study is confined to the period 2002 to 2016.
Detailed Description
In chronic intestinal failure patients receiving home parenteral support (HPS), catheter-related bloodstream infections (CRBSIs) frequently results in replacement of their tunneled central venous catheters (CVCs) which may lead to future loss of central venous access. This observational study investigates the consequences of a catheter-salvage-strategy related to CRBSIs according to different causative microorganisms, and short- and long-term risk of recurrence of the CRBSI. The study is based on the Copenhagen Intestinal failure database, which is a web-based database with retrospective data collection performed by reviews of medical charts from all adult intestinal failure patients discharged with home parenteral support from the Department of Medical Gastroenterology, Rigshospitalet.
Investigators
Palle Bekker Jeppesen
Professor, MD
Rigshospitalet, Denmark
Eligibility Criteria
Inclusion Criteria
- •chronic intestinal failure dependent on home parenteral support and enrolled in the Copenhagen Intestinal failure database
Exclusion Criteria
- •Never discharged on home parenteral support
Outcomes
Primary Outcomes
new catheter-related bloodstream infections
Time Frame: 2002 to 2016
The occurrence of catheter-related bloodstream infection after either catheter salvaged (retained central venous catheter) or replaced central venous catheter (new central venous catheter)
Secondary Outcomes
- recurrent catheter-related bloodstream infections(2002 to 2016)
- relapse catheter-related bloodstream infection(2002 to 2016)
- primary salvage rate(2002 to 2016)