miRNA Profile in Aneurysmal Subarachnoid Haemorrhage

Completed

• Conditions: Subarachnoid Hemorrhage

• Registration Number: NCT03344744
• Lead Sponsor: Chinese University of Hong Kong

Brief Summary

The investigators aim to investigate and understand the circulating miRNA profiles after acute aneurysmal subarachnoid haemorrhage and underlying pathological significance.

Detailed Description

1. The investigators aim to investigate the miRNA classifier for delayed cerebral infarction after aneurysmal subarachnoid haemorrhage;

2. The investigators aim to investigate the corresponding circulating and CSF miRNA profiles.

Study Timeline

• Study First Submitted: 2017-10-12
• Study First Submitted QC: 2017-11-13
• Study First Posted: 2017-11-17
• Study Start: 2017-11-30
• Primary Completion: 2023-08-31
• Study Completion: 2023-08-31
• Status Verified: 2023-09
• Last Update Submitted: 2023-09-06
• Last Update Posted: 2023-09-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Aneurysmal subarachnoid hemorrhage patients within the first 72 hours or Healthy volunteers

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Exclusion Criteria

Previous neurological diseases such as stroke or dementia

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Circulating micro RNA concentrations	Day 3	Serum micro RNA concentrations

Secondary Outcome Measures

Name	Time	Method
Circulating micro RNA change	Days 1,2,3,7	Changes of serum micro RNA concentrations between days 1,2,3,7
Cerebrospinal fluid micro RNA concentrations	Day 1,2,3,7	Cerebrospinal fluid micro RNA concentrations
Cerebrospinal fluid micro RNA change	Days 1,2,3,7	Changes of cerebrospinal fluid micro RNA concentrations between days 1,2,3,7

Trial Locations

Locations (1)

Department of Surgery, The Chinese University of Hong Kong; 🇨🇳 Hong Kong, China