Evaluation of Antimicrobial Efficacy of Green Tea, Garlic With Lime, Pomegranate Extract and Chlorhexidine Mouth Rinses in a Group of Egyptian Children (In-Vivo Study)

Not Applicable

Completed

• Conditions: Dental Caries
• Interventions: Procedure: Pomegranate extract mouth rinse; Procedure: Garlic with lime extract mouth rinse; Procedure: Chlorhexidine mouth rinse; Procedure: Green tea extract mouth rinse

• Registration Number: NCT05841589
• Lead Sponsor: omnia sayed

Brief Summary

the aim of the clinical trial is to evaluate the antimicrobial efficacy of the herbal mouth rinses against chlorhexidine mouth rinse.

Detailed Description

The present study was carried out on 84 children. Children were recruited based on certain inclusion criteria after signing a written informed consent by their parents. They were divided into 4 groups. Group (I) the children rinsed with Chlorhexidine mouth rinse, the child rinsed for 1 minute and plaque samples were collected from the child before and after rinsing. Group (II) children rinsed with green tea extract, while group (III) children rinsed with garlic with lime extract and group (IV) the children rinsed with pomegranate extract mouth rinse with the same procedures. .child satisfaction was measured using 5-point pictorial likert scale which is graded from 1 to 5 (1.Excellent.2.Good.3 Average 4.Poor. 5. Very poor).

All the plaque samples were collected and put in sterile test tubes containing thioglycolate as a transport media. They transferred to the microbiology laboratory within half an hour after rinsing for detection of bacterial counts. These samples were incubated 48-96 hours at 37°C. Number of bacterial colonies were counted by hand-held digital colony counter.

Study Timeline

• Study Start: 2018-02-21
• Primary Completion: 2021-11-30
• Study Completion: 2021-12-01
• Study First Submitted: 2023-03-27
• Status Verified: 2023-04
• Study First Submitted QC: 2023-05-02
• Last Update Submitted: 2023-05-02
• Study First Posted: 2023-05-03
• Last Update Posted: 2023-05-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 84

Inclusion Criteria

• Age 5-8 years.

• No history of systemic disease.
• Patients didn't received antibiotics for at least 3 months before and during the study

Exclusion Criteria

• Children who can't expectorate completely or brush their teeth on their own.

• Fixed or removable orthodontic appliances.
• Children with intra oral abscess, oral lesions or gingival diseases.
• Parental consent was not acquired

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Pomegranate extract mouth rinse	Pomegranate extract mouth rinse	pomegranate extract
Garlic with lime extract mouth rinse	Garlic with lime extract mouth rinse	garlic with lime extract
Chlorhexidine mouth rinse	Chlorhexidine mouth rinse	chlorhexidine
Green tea extract mouth rinse	Green tea extract mouth rinse	group green tea extract

Primary Outcome Measures

Name	Time	Method
patient satisfaction	Through study completion, an average of 1 month	Child satisfaction was measured using a 5-point pictorial likert scale .This Facial image scale was suitable and easy way to evaluate patient satisfaction about taste, smell and willing to use the mouth rinse. Its format was graded from 1 to 5 while 1 is the most satisfied and 5 is the least satisfied

Secondary Outcome Measures

Name	Time	Method
bacterial count	1 day after rinsing	counting of Colony forming units was done by hand- held digital colony counter

Trial Locations

Locations (1)

Ain Shmas University; 🇪🇬 Cairo, Egypt