Association Between Preoperative Hyperglycemia and Postoperative Delirium in Geriatric Hip Fracture Patients

Completed

• Conditions: Hyperglycemia; Hip Fractures; Postoperative Delirium

• Registration Number: NCT06473324
• Lead Sponsor: Wenbo Ding

Brief Summary

This retrospective study aims to collect electronic medical record data from Dandong central hospital spanning from January 2013 to November 2023. The collected data does not contain any personally identifiable information or breach privacy. Additionally, this study design does not involve active intervention measures or patient recruitment. The research aims to investigate the correlation between preoperative blood glucose levels in elderly hip fracture patients and postoperative delirium.

Detailed Description

A retrospective observational study is planned to explore specific phenomena or associations using electronic medical record data. The collected data does not contain any personally identifiable information or compromise privacy. Additionally, this study design does not involve active intervention measures or patient recruitment. The study data is sourced from the electronic medical record system of hospitalized patients and has received approval from the hospital's research center, with ongoing supervision by the hospital's ethics committee. The study aims to investigate the correlation between preoperative blood glucose levels in hip fracture patients and postoperative complications.

The retrospective study aims to collect electronic medical record data spanning from January 2013 to November 2023. The data collection process is consistently monitored and verified by the hospital's ethics committee. Throughout the study, adherence to the ethical principles outlined in the 1964 Helsinki Declaration is ensured, and institutional review board (IRB) approval has been obtained for all aspects of the research.

The study aims to provide valuable evidence-based medicine for clinical practitioners by examining the relationship between preoperative persistent hyperglycemia in elderly hip fracture patients and postoperative delirium. Furthermore, it seeks to offer clinical insights for early identification and intervention management of high-risk postoperative delirium patients (POD).

Study Timeline

• Study Start: 2023-11-21
• Primary Completion: 2024-01-01
• Study Completion: 2024-01-03
• Status Verified: 2024-06
• Study First Submitted: 2024-06-18
• Study First Submitted QC: 2024-06-22
• Last Update Submitted: 2024-06-22
• Study First Posted: 2024-06-25
• Last Update Posted: 2024-06-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 2031

Inclusion Criteria

1. Patients who have undergone surgical treatment for hip fractures.

Exclusion Criteria

1. Multiple or pathological hip fractures.
2. Emergent surgery.
3. Age below 60 years.
4. Incomplete electronic medical records or preoperative blood glucose levels were assessed fewer than two times.
5. Presence of neurological and psychiatric disorders, except dementia.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of Participants with Postoperative Delirium	up to 2 months	Postoperative Delirium (POD) manifests as acute cognitive dysfunction and consciousness disorder, characterized by changes in attention or consciousness that cannot be attributed to pre-existing cognitive impairments. Typical symptoms include hallucinations, delusions, agitated behavior, disordered speech, decreased attention, confusion, unclear consciousness, and disrupted sleep-wake cycles. Moreover, POD typically occurs within the first five days after surgery, particularly within the initial 48 hours, and exhibits significant fluctuations.

Trial Locations

Locations (1)

Dandong Central Hospital; 🇨🇳 Dandong, Liaoning, China