Individualized Prevention Strategy for High Risk Patients in Cardiovascular Disease: Prospective Cohort Study (Cardiovascular and Metabolic Disease Etiology Research Center - HIgh Risk Cohort) CMERC-HI

• Conditions: High Risk Cardiovascular Disease Patients

• Registration Number: NCT02003781
• Lead Sponsor: Yonsei University

Brief Summary

Set the prospective cohort (CMERC-HI) to study the known and novel etiologies and related factors for predicting clinical outcomes in Korean patients with high risk cardiovascular disease.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2013-10
• Study First Submitted: 2013-12-02
• Study First Submitted QC: 2013-12-02
• Study First Posted: 2013-12-06
• Status Verified: 2018-07
• Last Update Submitted: 2018-07-15
• Last Update Posted: 2018-07-17
• Primary Completion: 2023-10
• Study Completion: 2023-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 4000

Inclusion Criteria

• high risk hypertension patients a. eGFR > 60 with one of target organ damages b. eGFR <= 60
• diabetes mellitus with microalbumin ration (AC ratio >= 30mg/g)
• anuric ESRD patients on dialysis
• the relatives of acute myocardial infarction patients under 55 years old (men)/ 65 years old (women)
• atherosclerotic cardiovascular disease (abdominal aorta diameter ≥3 cm or ankle-brachial index <0.9, or carotid plaque or carotid intima-media thickness ≥0.9 mm, or asymptomatic old cerebrovascular accident, or >30% stenosis in at least one major coronary artery)
• rheumatoid arthritis patients aged > 40 years on MTX and steroid therapy
• atrial fibrillation patients with CHADS-VASc Score ≥ 1
• kidney transplant recipient at > 3 months after transplantation

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Exclusion Criteria

• acute myocardial infarction, acute coronary syndrome patients, symptomatic coronary artery disease or history of these diseases
• symptomatic peripheral artery disease, heart failure and history of these diseases
• desired life time under 6 months due to non-cardiovascular disease (e.g. cancer, sepsis)
• women with pregnancy or on nursing
• history of contrast allergy and related side effects
• within the first three months after transplantation
• acute renal allograft rejection

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prognosis of high risk cardiovascular disease	10 year after recruting	all-cause mortality, cardiovascular mortality, non-cardiovascular mortality; new onset of acute myocardial infarction, acute coronary syndrome, heart failure, stroke, peripheral artery disease, hospitalization for revascularization and these disease

Trial Locations

Locations (1)

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine; 🇰🇷 Seoul, Korea, Republic of