Individualized Prevention Strategy for High Risk Patients in Cardiovascular Disease: Prospective Cohort Study (Cardiovascular and Metabolic Disease Etiology Research Center - HIgh Risk Cohort) CMERC-HI

Yonsei University1 site in 1 country4,000 target enrollmentOctober 2013

ConditionsHigh Risk Cardiovascular Disease Patients

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: High Risk Cardiovascular Disease Patients
Sponsor: Yonsei University
Enrollment: 4000
Locations: 1
Primary Endpoint: Prognosis of high risk cardiovascular disease
Last Updated: 7 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Set the prospective cohort (CMERC-HI) to study the known and novel etiologies and related factors for predicting clinical outcomes in Korean patients with high risk cardiovascular disease.

Registry

clinicaltrials.gov

Start Date

October 2013

End Date

October 2023

Last Updated

7 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Yonsei University

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•high risk hypertension patients a. eGFR \> 60 with one of target organ damages b. eGFR \<= 60
•diabetes mellitus with microalbumin ration (AC ratio \>= 30mg/g)
•anuric ESRD patients on dialysis
•the relatives of acute myocardial infarction patients under 55 years old (men)/ 65 years old (women)
•atherosclerotic cardiovascular disease (abdominal aorta diameter ≥3 cm or ankle-brachial index \<0.9, or carotid plaque or carotid intima-media thickness ≥0.9 mm, or asymptomatic old cerebrovascular accident, or \>30% stenosis in at least one major coronary artery)
•rheumatoid arthritis patients aged \> 40 years on MTX and steroid therapy
•atrial fibrillation patients with CHADS-VASc Score ≥ 1
•kidney transplant recipient at \> 3 months after transplantation

Exclusion Criteria

•acute myocardial infarction, acute coronary syndrome patients, symptomatic coronary artery disease or history of these diseases
•symptomatic peripheral artery disease, heart failure and history of these diseases
•desired life time under 6 months due to non-cardiovascular disease (e.g. cancer, sepsis)
•women with pregnancy or on nursing
•history of contrast allergy and related side effects
•within the first three months after transplantation
•acute renal allograft rejection

Outcomes

Primary Outcomes

Prognosis of high risk cardiovascular disease

Time Frame: 10 year after recruting

all-cause mortality, cardiovascular mortality, non-cardiovascular mortality new onset of acute myocardial infarction, acute coronary syndrome, heart failure, stroke, peripheral artery disease, hospitalization for revascularization and these disease