NCT02003781UnknownNot Applicable
Individualized Prevention Strategy for High Risk Patients in Cardiovascular Disease: Prospective Cohort Study (Cardiovascular and Metabolic Disease Etiology Research Center - HIgh Risk Cohort) CMERC-HI
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Yonsei University
- Enrollment
- 4,000
- Locations
- 1
- Primary Endpoint
- Prognosis of high risk cardiovascular disease
Study Overview
Brief Summary
Set the prospective cohort (CMERC-HI) to study the known and novel etiologies and related factors for predicting clinical outcomes in Korean patients with high risk cardiovascular disease.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 20 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •high risk hypertension patients a. eGFR > 60 with one of target organ damages b. eGFR <= 60
- •diabetes mellitus with microalbumin ration (AC ratio >= 30mg/g)
- •anuric ESRD patients on dialysis
- •the relatives of acute myocardial infarction patients under 55 years old (men)/ 65 years old (women)
- •atherosclerotic cardiovascular disease (abdominal aorta diameter ≥3 cm or ankle-brachial index <0.9, or carotid plaque or carotid intima-media thickness ≥0.9 mm, or asymptomatic old cerebrovascular accident, or >30% stenosis in at least one major coronary artery)
- •rheumatoid arthritis patients aged > 40 years on MTX and steroid therapy
- •atrial fibrillation patients with CHADS-VASc Score ≥ 1
- •kidney transplant recipient at > 3 months after transplantation
Exclusion Criteria
- •acute myocardial infarction, acute coronary syndrome patients, symptomatic coronary artery disease or history of these diseases
- •symptomatic peripheral artery disease, heart failure and history of these diseases
- •desired life time under 6 months due to non-cardiovascular disease (e.g. cancer, sepsis)
- •women with pregnancy or on nursing
- •history of contrast allergy and related side effects
- •within the first three months after transplantation
- •acute renal allograft rejection
Outcomes
Primary Outcomes
Prognosis of high risk cardiovascular disease
Time Frame: 10 year after recruting
all-cause mortality, cardiovascular mortality, non-cardiovascular mortality new onset of acute myocardial infarction, acute coronary syndrome, heart failure, stroke, peripheral artery disease, hospitalization for revascularization and these disease
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (1)
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