A Prospective Cohort Study of Atrial Fibrillation Patients Treated With Catheter Ablation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Atrial Fibrillation
- Sponsor
- Peking Union Medical College Hospital
- Enrollment
- 300
- Locations
- 1
- Primary Endpoint
- Recurrence assessed by ECG, Holter reports and outpatient physicians
- Status
- Recruiting
- Last Updated
- 11 months ago
Overview
Brief Summary
This is a single-center prospective observational cohort study of atrial fibrillation patients treated with radiofrequency ablation.
Detailed Description
The effect of radiofrequency therapy on the life quality and atrial function of atrial fibrillation patients will be assessed, through the multidimensional analysis of baseline clinical data, serological indicators of atrial fibrosis, echocardiography, cardiac magnetic resonance imaging, atrial potential mapping, life quality, and long-term ECG monitoring within 1 week after radiofrequency ablation. A predictive model for atrial fibrillation recurrence after ablation will be established. Based on the cross-sectional analysis of baseline data, the relationship between non-invasive assessment of atrial fibrosis (imaging and serology), atrial electrical activity, and atrial function will be analyzed as well, and atrial fibrillation patients with ventricular fibrosis will be selected for gene sequencing to explore the existence of underlying cardiomyopathy and provide data for further research.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Non-valvular atrial fibrillation, including paroxysmal atrial fibrillation and persistent atrial fibrillation
- •18-80 years old
- •The anteroposterior diameter of the left atrium is less than 50mm via TTE
- •Patient meets the intervention criteria for bilateral pulmonary vein isolation after evaluation by electrophysiological specialists
- •Patient consents to ablation treatment
Exclusion Criteria
- •Intra-atrial thrombus detected by TEE
- •Hyperthyroidism
- •Previous radiofrequency ablation for atrial fibrillation
Outcomes
Primary Outcomes
Recurrence assessed by ECG, Holter reports and outpatient physicians
Time Frame: at 1-year follow-up after ablation
Recurrence includes atrial fibrillation and atrial flutter. Recurrence features including pattern, duration, burden, etc. will be recorded.
All-cause mortality assessed by telephone follow-up or medical records
Time Frame: at 1-year follow-up after ablation
Time and cause of death will be recorded.
Secondary Outcomes
- Improvement in life quality assessed by QOLSF36 Questionnaire(at 1-year follow-up after ablation)
- Embolic events assessed by physicians and further examinations like ultrasound, MRI(at 1-year follow-up after ablation)
- Improvement in left atrial function assessed by echocardiography(at 1-year follow-up after ablation)
- Hospitalization for heart failure, atrial fibrillation or atrial flutter(at 1-year follow-up after ablation)