Sulodexide effect on walking ability in patients with intermittent claudicatio

• Conditions: Intermittent claudication; Peripheral arterial occlusive disease; Cardiovascular - Diseases of the vasculature and circulation including the lymphatic system

• Registration Number: ACTRN12611000721909
• Lead Sponsor: Georges Tabet

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-07-12
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Typical intermittent claudication confirmed by a reduced ankle brachial index (0.7 on the worst leg measured by a Doppler probe)
-A maximum initial walking distance between 30 and 500 m measured by a treadmill test
-A maximum change in initial walking distance inferior to 25% on two treadmill tests performed before the inclusion of the patients
-Stability of the patient conditions for the last month

Exclusion Criteria

-An acute deterioration of the patient condition in the last month.
-High variability in walking distances,
-Illness limiting the exercise capacity: uncontrolled hypertension, angina pectoris, unstable angina, severe cardiac conduction abnormalities, uncontrolled congestive heart failure, respiratory diseases, orthopedic diseases, neurological disorders
-History of hypersensitivity to extractive mucopolysaccharides
-Severe hemodynamic stenosis of pelvic arteries
-Inflammatory vascular diseases (e.g. thromboangeitis, immunoangiopathy, vascular and collagen disorders);
-Aneurysm of the abdominal aorta

Study & Design

• Study Type: Interventional
• Study Design: Not specified