Generation of Organoids of Neuroendocrine Neoplasms of the Gastro-Entero-Pancreatic Tract Obtained From Patients Undergoing Surgery
- Conditions
- Gastro-entero-pancreatic Neoplasms
- Registration Number
- NCT06519500
- Lead Sponsor
- Regina Elena Cancer Institute
- Brief Summary
Observational, prospective, feasibility pilot study of the preparation of organoids starting from tumor tissue and surrounding healthy tissue, collected during surgery, performed according to standard clinical practice.
- Detailed Description
Given the need for the use of experimental models that mimic the tumor of origin
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 40
- over 18 years of age;
- diagnosis of GEP-NEN carried out via histological investigation or via positivity to the uptake PET-CT with 68Ga-peptides;
- availability of adequate material for the preparation of organoid cultures, derived from surgery;
- written informed consent.
- previous chemotherapy treatments
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Set up of at least 10 organoid cultures 42 months The organoids will be generated from tumor tissue samples and surrounding healthy tissue obtained from patients affected by GEP-NEN (who meet the inclusion/exclusion criteria) collected, according to clinical practice, during tumor resection surgery. Only the excess material after carrying out all the investigations necessary for the correct diagnosis histological analysis can be used for the purpose of the project
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
"Regina Elena" National Cancer Institute
🇮🇹Rome, Italy