Effects of Transcutaneous Electrical Nerve Stimulation on Cortical Excitability in the Primary Motor Cortex in Healthy Adults
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Chang Gung University
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- intracortical facilitation, ICF
Study Overview
Brief Summary
Recently, non-invasive brain stimulation has become a powerful tool in both basic research and clinical application. Among several non-invasive brain stimulation techniques, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have received the most attention. About DC stimulation, the change of polarity could modulate the spontaneous neuronal activity and make effect on decision making, language, memory, sensory perception, and pain. In spite of that the concept of transcranial alternating current stimulation (tACS) is not novel, AC is relatively safe compared to DC, and researches have revealed that AC might potentially have the effect on the cortical excitability. However, there are still many areas about AC stimulation which remain unknown, such as mechanism, application, and potential influence on cortical excitability.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 20 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy adults
Exclusion Criteria
- Not provided
Arms & Interventions
5Hz alternating current stimulation group
Intervention: transcutaneous electrical nerve stimulation, TENS (Device)
sham alternating current stimulation group
Intervention: transcutaneous electrical nerve stimulation, TENS (Device)
120Hz alternating current stimulation group
Intervention: transcutaneous electrical nerve stimulation, TENS (Device)
Outcomes
Primary Outcomes
intracortical facilitation, ICF
Time Frame: Baseline,Baseline,2 hours, 2.5 hours,and 3 hours
Measure of changes in intracortical inhibition on abductor pollicis brevis by paired-pulse TMS.
Motor evoked potential
Time Frame: Baseline
measure of intracortical inhibition on abductor pollicis brevis by single-pulse TMS.
Intracortical inhibition, ICI
Time Frame: Baseline,2 hours, 2.5 hours,and 3 hours
Measure of changes in intracortical inhibition on abductor pollicis brevis by paired-pulse TMS.
Secondary Outcomes
No secondary outcomes reported
Investigators
Ya-Ju Chang
Professor
Chang Gung University