The rationale of study is that which one among Nalbuphine and Buprenorphine,is a better adjuvant yet to be explored as only few studies happened in past on this

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2023/03/050389
• Lead Sponsor: ROHILKHAND MEDICAL COLLEGE AND HOSPITAL

Brief Summary

Subarachnoid block is used in lower abdominal and lower limb surgeries for post operative pain relief. Opiod drugs have been used along with Bupivacaine and other local anaesthetics in subarachnoid block for prolongation of effect of analgesia and to minimise the requirement of postoperative analgesia

Bupivacaine is an amino amide anesthetic binds to intracellular portion of voltage gated sodium channels and blocks sodium influx into nerves cells which prevent depolarisation so no initiation or conduction of pain signal occur



Buprenorphine is derivative of opiod alkaloid thebaine , provide good intraoperative and postoperartive analgesia. Nalbuphine is highly lipid soluble kappa receptor agonist and mu receptor anatagonist

The Rationale of study is that which among Nalbuphine and Buprenorphine is better adjuvant yet to be explored and only few studies happened in past on it

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-03-03
• Study Start: 2023-12-03

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

American society of Anesthesiologists (ASA) grade 1 or 2 Posted for surgeries of lower abdomen or lower limb of different surgical specialities.

Exclusion Criteria

Patient refusal for procedure Any Neuropathy,Cardiac disease,diabetes,Nephropathy,Coagulopathy Any known allergy to local anaesthetic Patients with contraindications for spinal anaesthesia such as derranged coagulation profile ,raised ICP,local infection at site of needle insertion.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Onset of sensory and motor block	At 2,4,6,8,10,12,14,16,18,20,30,40,50,60,90,120,180,240,360,720 minutes after block , heart rate ,ECG lead 2 ,systolic , diastolic and mean blood pressure and oxygen saturation will be recorded
Duration of sensory and motor block	At 2,4,6,8,10,12,14,16,18,20,30,40,50,60,90,120,180,240,360,720 minutes after block , heart rate ,ECG lead 2 ,systolic , diastolic and mean blood pressure and oxygen saturation will be recorded
Duration of postoperative analgesia	At 2,4,6,8,10,12,14,16,18,20,30,40,50,60,90,120,180,240,360,720 minutes after block , heart rate ,ECG lead 2 ,systolic , diastolic and mean blood pressure and oxygen saturation will be recorded

Secondary Outcome Measures

Name	Time	Method
Hemodynamic responses to the drug during and after surgery	Any complication or side effects

Trial Locations

Locations (1)

OPERATION THEATRE , Rohilkhand Medical College And Hospital; 🇮🇳 Bareilly, UTTAR PRADESH, India

OPERATION THEATRE , Rohilkhand Medical College And Hospital

🇮🇳Bareilly, UTTAR PRADESH, India

Dr Sarfaraz Ahmad

Principal investigator

7088833111

sarfaraz_ahm2000@yahoo.com