Comparison of the effects of intravenous propofol and intravenous propofol with low dose of ketamine on preventing post-extubation cough and laryngospasm in patient awakening from general anesthesia: a prospective randomized clinical trial.
Phase 4
Completed
- Conditions
- Prevention of incidence and severity of cough and laryngospasm
- Registration Number
- TCTR20191125001
- Lead Sponsor
- Phramongkutklao Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
ASA physical status I and II, with airway assessment of Mallampati grade 1 and 2, between the age group of 18-60 years, scheduled for elective surgeries under general anesthesia.
Exclusion Criteria
unwilling patients, history of allergy to any drug, history of bronchial asthma, chronic obstructive pulmonary disease, respiratory tract infection, impaired kidney or liver function, on angiotensin converting enzyme inhibitors, a history of hypersensitivity to local anesthetics, pregnancy and language barrier.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence and severity of coughing and laryngospasm Within 2 minutes after extubation The severity of coughing was graded as (0=no incidence of coughing, 1=only one cough, 2= two coughs
- Secondary Outcome Measures
Name Time Method Incidence and severity of laryngospasm Within 2 minutes after extubation Laryngospasm was graded according as 0 = no symptoms,1=stridor , 2= total occlusion of the cords (