Flat colonic neoplasms: a population-based study

Recruiting

Conditions: Colorectaal carcinoom, Darmpoliepen, Poliepen, Adenomen, Vlak, Non-polypoid, Laterally Spreading Tumors, Serrated lesions

Lead Sponsor: Maastricht University Medical Center (MUMC+), Department of Gastroenterology and Hepatology

Brief Summary: Rondagh EJ, Masclee AA, Bouwens MW et al. Endoscopic red flags for the detection of high-risk serrated polyps: an observational study. Endoscopy 2011; 43: 1052-1058 - Rondagh EJ, Sanduleanu S, le Clercq CM et al. Diverticulosis and colorectal polyps at younger age: a possible link? Eur J Gastroenterol Hepatol 2011; 23: 1050-1055 - Rondagh EJ, Bouwens MW, Riedl RG et al. Endoscopic appearance of proximal colorectal neoplasms and potential implications for colonoscopy in cancer prevention. Gastrointest Endosc 2012; 75: 1218-1225 - Rondagh EJ, Masclee AA, van der Valk ME et al. Nonpolypoid colorectal neoplasms: gender differences in prevalence and malignant potential. Scand J Gastroenterol 2012; 47: 80-88 - Bouwens MW, Riedl RG, Bosman FT et al. Large proximal serrated polyps: natural history and colorectal cancer risk in a retrospective series. J Clin Gastroenterol 2013; 47: 734-735 - Bouwens MW, Winkens B, Rondagh EJ et al. Simple clinical risk score identifies patients with serrated polyps in routine practice. Cancer Prev Res (Phila) 2013; 6: 855-863

Recruitment & Eligibility

Inclusion Criteria

Patients referred for routine colonoscopy with or without positive familiy history for colorectal cancer.

Exclusion Criteria

Patients with a history of inflammatory bowel disease, polyposis syndrome and proved mutations (APC, MUTYH, MMR) are excluded from analysis.

Primary Outcome Measures

Name	Time	Method
1. Prevalence of flat colorectal lesions in a Dutch population, especially the prevalence of Laterally Spreading Tumors;<br /><br>2. Clinical characteristics (e.g. location of lesions, percentage of high-grade dysplasia or early cancer);<br><br /><br>3. Molecular charcteristics (epigenetic: methylation status and genetic) of flat vs. polypoid colorectal lesions;<br /><br>4. Prevalence of flat advanced colorectal cancers vs. polypoid advanced colorecal cancers: clinical features of these lesions (e.g. tumor stage);<br /><br>5. Relation between serrated and adenomatous polyps.

Secondary Outcome Measures