LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis
- Conditions
- Metabolic Dysfunction Associated Steatohepatitis (MASH)Liver Fibrosis
- Interventions
- Drug: Placebo
- Registration Number
- NCT06632444
- Lead Sponsor
- Boehringer Ingelheim
- Brief Summary
This study is open to adults who are at least 18 years old and have:
* a confirmed liver disease called non-alcoholic steatohepatitis (NASH)/metabolic-associated steatohepatitis (MASH) and
* moderate or advanced liver fibrosis
People with a history of acute or chronic liver diseases other than MASH or chronic alcohol intake cannot take part in this study. The purpose of this study is to find out whether a medicine called survodutide helps people with MASH and moderate or advanced liver fibrosis improve their liver function.
This study has 2 parts. The purpose of the first part of this study is to find out the effect of survodutide on MASH and liver fibrosis. The purpose of the second part is to find out how safe and effective survodutide is in improving liver function.
Participants are put into 2 groups randomly, which means by chance. 1 group gets survodutide and 1 group gets placebo. Placebo looks like survodutide but does not contain any medicine. Each participant has twice the chance of getting survodutide. Participants and doctors do not know who is in which group. Participants inject survodutide or placebo under their skin once a week. The survodutide doses are slowly increased until the target dose is reached. All participants receive counselling to make changes to their diet and to exercise regularly.
Participants are in the study for up to 7 years. During this time, they regularly visit the study site or have remote visits by video call. For about the first year of the study, participants have these visits every 2 weeks, increasing to every 4 weeks and then every 6 weeks. After being in the study for a little over a year participants will then alternate between visiting the study site or having a remote visit every 3 months until the end of the study.
The doctors check participants' health and take note of any unwanted effects. The participants' body weight and effects on the stomach and intestines are regularly measured. At some visits the liver is measured using different imaging methods. At 2 or 3 visits doctors take a small sample of liver tissue (biopsy). The participants also fill in questionnaires about their symptoms and quality of life. The results are compared between the groups to see whether the treatment works.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 1800
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Survodutide Survodutide - Placebo Placebo -
- Primary Outcome Measures
Name Time Method Part 1: Resolution of MASH without worsening of liver fibrosis on MASH Clinical Research Network (CRN) fibrosis score Baseline and at Week 52. Part 1: At least a 1-point improvement in fibrosis stage with no worsening of MASH Baseline and at Week 52. Part 2: Time to first occurrence of any of components of the composite endpoint consisting of progression to cirrhosis, all-cause mortality, liver transplant, hepatic decompensation event(s), worsening of MELD score to ≥15, progression to CSPH Up to 7 years. Progression to cirrhosis is defined as histological fibrosis score CRN F4. MELD = Model for End-stage Liver Disease CSPH =clinically significant portal hypertension
- Secondary Outcome Measures
Name Time Method Key secondary endpoint part 2: Time to first occurrence of any of the adjudicated components of the composite endpoint 5-point major adverse cardiac event (5P-MACE)5-point major adverse cardiac event (5P-MACE) Up to 7 years. Part 1: Improvement of liver fat content (LFC) At baseline and at Week 52. Defined as at least 30% relative reduction in LFC compared with baseline assessed by Magnetic resonance imaging proton density fat fraction (MRI-PDFF).
This endpoint will be reported only for a subset of participants in the MRI sub-study.Part 2: Improvement of LFC At baseline and at Week 114. Defined as at least 30% relative reduction in LFC compared with baseline assessed by MRI-PDFF.
This endpoint will be reported only for a subset of participants in the MRI sub-study.Part 1: Absolute change from baseline in LFC [%] in MRI-PDFF At baseline and at Week 52. This endpoint will be reported only for a subset of participants in the MRI sub-study.
Part 2: Absolute change from baseline in LFC [%] in MRI-PDFF At baseline and at Week 114. This endpoint will be reported only for a subset of participants in the MRI sub-study.
Part 1: Absolute change from baseline in alanine aminotransferase (ALT) [U/L] At baseline and at Week 52. Part 2: Absolute change from baseline in alanine aminotransferase (ALT) [U/L] At baseline and at Week 114. Part 1: Absolute change from baseline in aspartate aminotransferase (AST) [U/L] At baseline and at Week 52. Part 2: Absolute change from baseline in aspartate aminotransferase (AST) [U/L] At baseline and at Week 114. Part 1: Absolute change from baseline in systolic blood pressure (SBP) [mmHg] At baseline and at Week 52. Part 2: Absolute change from baseline in systolic blood pressure (SBP) [mmHg] At baseline and at Week 114. Part 1: Absolute change from baseline in diastolic blood pressure (DBP) [mmHg] At baseline and at Week 52. Part 2: Absolute change from baseline in diastolic blood pressure (DBP) [mmHg] At baseline and at Week 114. Part 1: Absolute changes from baseline in lipids [mg/dL] (including but not limited to: total cholesterol, LDL cholesterol, very low-density lipoprotein [VLDL] cholesterol, high-density lipoprotein [HDL] cholesterol, triglycerides) At baseline and at Week 52. LDL=low-density lipoprotein
Part 2: Absolute changes from baseline in lipids [mg/dL] (including but not limited to: total cholesterol, LDL cholesterol, very low-density lipoprotein [VLDL] cholesterol, high-density lipoprotein [HDL] cholesterol, triglycerides) At baseline and at Week 114. Part 1: Absolute change from baseline in free fatty acids [mg/dL] At baseline and at Week 52. Part 2: Absolute change from baseline in free fatty acids [mg/dL] At baseline and at Week 114. Part 1: Progression to cirrhosis (defined as histological fibrosis score CRN F4) (yes/no) At baseline and at Week 52. Key secondary endpoint part 1: Percentage change from baseline in body weight [kg] Baseline and at Week 52. Key secondary endpoint part 1: Absolute change from baseline in glycosylated haemoglobin (HbA1c) [%] Baseline and at Week 52. This endpoint is specified only for the participants with type 2 diabetes mellitus.
Key secondary endpoint part 1: Absolute change from baseline in enhanced liver fibrosis (ELF) score Baseline and at Week 52. Key secondary endpoint part 1: Absolute change from baseline in liver stiffness [kPa] assessed by vibration-controlled transient elastography (VCTE) Baseline and at Week 52. Key secondary endpoint part 1: Achievement of no progression of fibrosis assessed by central pathology (yes/no) Baseline and at Week 52. Key secondary endpoint part 2: Percentage change from baseline in body weight [kg] At baseline and at Week 114 Key secondary endpoint part 2: Absolute change from baseline in HbA1c [%] At baseline and at Week 114 This endpoint is specified only for the participants with type 2 diabetes mellitus.
Key secondary endpoint part 2: Absolute change from baseline in ELF score At baseline and at Week 114. Key secondary endpoint part 2: Absolute change from baseline in liver stiffness [kPa] assessed by VCTE At baseline and at Week 114. Key secondary endpoint part 2: Achievement of no progression of fibrosis assessed by central pathology (yes/no) At baseline and at 7 years. Key secondary endpoint part 2: Occurrence of all-cause hospitalisation (first and recurrent) Up to 7 years.
Trial Locations
- Locations (447)
Arizona Liver Health-Chandler-68733
🇺🇸Chandler, Arizona, United States
The Institute for Liver Health, LLC
🇺🇸Tucson, Arizona, United States
Scottsdale Clinical Trials
🇺🇸Scottsdale, Arizona, United States
Adobe Clinical Research, LLC
🇺🇸Tucson, Arizona, United States
Del Sol Research Management, LLC
🇺🇸Tucson, Arizona, United States
Hope Clinical Research
🇺🇸Canoga Park, California, United States
Velocity Clinical Research-Chula Vista-67286
🇺🇸Chula Vista, California, United States
Southern California Research Center
🇺🇸Coronado, California, United States
Velocity Clinical Research-Gardena-69773
🇺🇸Gardena, California, United States
Velocity Clinical Research-Huntington Park-68988
🇺🇸Huntington Park, California, United States
310 Clinical Research
🇺🇸Inglewood, California, United States
Velocity Clinical Research, San Diego
🇺🇸La Mesa, California, United States
Om Research, LLC
🇺🇸Lancaster, California, United States
ARK Clinical Research
🇺🇸Long Beach, California, United States
Velocity Clinical Research, Westlake
🇺🇸Los Angeles, California, United States
Catalina Research Institute, LLC-Montclair-69754
🇺🇸Montclair, California, United States
Velocity Clinical Research - Boise
🇺🇸North Hollywood, California, United States
Clinnova Research Solutions
🇺🇸Orange, California, United States
Fomat Medical Research
🇺🇸Oxnard, California, United States
Cadena Care Institute, Llc
🇺🇸Poway, California, United States
Ficramed Research Institute
🇺🇸Poway, California, United States
Inland Empire Clinical Trials, LLC
🇺🇸Rialto, California, United States
Metro Clinical Trials
🇺🇸San Bernardino, California, United States
Acclaim Clinical Research
🇺🇸San Diego, California, United States
Velocity Clinical Research-Santa Ana-68902
🇺🇸Santa Ana, California, United States
Future Innovative Treatments
🇺🇸Colorado Springs, Colorado, United States
South Denver Gastroenterology PC
🇺🇸Englewood, Colorado, United States
Connecticut Gastroenterology Clinical Research Foundation
🇺🇸Bristol, Connecticut, United States
Synergy Healthcare
🇺🇸Brandon, Florida, United States
Access research Institute
🇺🇸Brooksville, Florida, United States
Tampa Bay Medical Research
🇺🇸Clearwater, Florida, United States
K2 Medical Research
🇺🇸Orlando, Florida, United States
Hi Tech and Global Research, LLC
🇺🇸Coral Gables, Florida, United States
Top Medical Research, Inc
🇺🇸Cutler Bay, Florida, United States
Covenant Metabolic Specialists, LLC-Fort Myers-69019
🇺🇸Fort Myers, Florida, United States
University of Florida
🇺🇸Gainesville, Florida, United States
Evolution Clinical Trials
🇺🇸Hialeah Gardens, Florida, United States
Floridian Clinical Research-Hialeah-66084
🇺🇸Hialeah, Florida, United States
Neoclinical Research
🇺🇸Hialeah, Florida, United States
Global Research Associates
🇺🇸Homestead, Florida, United States
ObjectiveHealth-Lake Center for Clinical Research
🇺🇸Lady Lake, Florida, United States
Research Associates of South Florida, LLC
🇺🇸Miami, Florida, United States
Optimus U Corporation-Miami-69452
🇺🇸Miami, Florida, United States
University of Miami
🇺🇸Miami, Florida, United States
BioMed Research & Medical Center
🇺🇸Miami, Florida, United States
MplusM - Century Research
🇺🇸Miami, Florida, United States
ECIR Miami Holdings LLC dba IMIC
🇺🇸Miami, Florida, United States
Entrust Clinical Research
🇺🇸Miami, Florida, United States
GI Pros Research
🇺🇸Naples, Florida, United States
Insight Clinical Research, LLC
🇺🇸New Port Richey, Florida, United States
Charter Research
🇺🇸The Villages, Florida, United States
Endoscopic Research, Inc
🇺🇸Orlando, Florida, United States
Omega Research Orlando, LLC
🇺🇸Orlando, Florida, United States
Innovation Medical Research Center
🇺🇸Palmetto Bay, Florida, United States
MplusM - Best Choice Medical and Research Service
🇺🇸Pembroke Pines, Florida, United States
Progressive Medical Research
🇺🇸Port Orange, Florida, United States
Global Clinical Professionals
🇺🇸Saint Petersburg, Florida, United States
Covenant Metabolic Specialists, LLC
🇺🇸Sarasota, Florida, United States
International Center for Research
🇺🇸Tampa, Florida, United States
Conquest Research
🇺🇸Winter Park, Florida, United States
Florida Medical Clinic, P.A.
🇺🇸Zephyrhills, Florida, United States
Piedmont Hospital
🇺🇸Atlanta, Georgia, United States
Center for Advanced Research & Education
🇺🇸Gainesville, Georgia, United States
Gastroenterology Associates of Central Georgia
🇺🇸Macon, Georgia, United States
ASHA Clinical Research - Munster, LLC
🇺🇸Hammond, Indiana, United States
Digestive Research Alliance of Michiana
🇺🇸South Bend, Indiana, United States
Iowa Diabetes and Endocrinology Research Center
🇺🇸West Des Moines, Iowa, United States
Tandem Clinical Research
🇺🇸Marrero, Louisiana, United States
Delta Research Partners, LLC
🇺🇸Monroe, Louisiana, United States
Louisiana Research Center, LLC
🇺🇸Shreveport, Louisiana, United States
Clinical Research Institute of Michigan, LLC
🇺🇸Clinton Township, Michigan, United States
West Michigan Clinical Research Center
🇺🇸Wyoming, Michigan, United States
MNGI Digestive Health, PA
🇺🇸Minneapolis, Minnesota, United States
Gastrointestinal Associates, PA
🇺🇸Flowood, Mississippi, United States
ObjectiveHealth-GI Associates Research
🇺🇸Columbia, Missouri, United States
Kansas City Gastroenterology & Hepatology Physicians Group
🇺🇸Kansas City, Missouri, United States
University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
Jubilee Clinical Research, Inc
🇺🇸Las Vegas, Nevada, United States
Excel Clinical Research
🇺🇸Las Vegas, Nevada, United States
Clinical Research of South Nevada
🇺🇸Las Vegas, Nevada, United States
IMA Clinical Research-Warren-69742
🇺🇸Warren, New Jersey, United States
New York Methodist Hospital in Brooklyn
🇺🇸Brooklyn, New York, United States
Basil Clinical
🇺🇸Inwood, New York, United States
University of Rochester Medical Center
🇺🇸Rochester, New York, United States
Carolina Digestive Diseases
🇺🇸Greenville, North Carolina, United States
Lucas Research, Inc.
🇺🇸Morehead City, North Carolina, United States
M3 Wake Research, Inc.
🇺🇸Raleigh, North Carolina, United States
The Ohio State University Wexner Medical Center
🇺🇸Columbus, Ohio, United States
Columbus Clinical Research Inc.
🇺🇸Columbus, Ohio, United States
Great Lakes Gastroenterology Research, LLC
🇺🇸Mentor, Ohio, United States
ObjectiveHealth-DSI Research
🇺🇸Springboro, Ohio, United States
Northshore Gastroenterology Research
🇺🇸Westlake, Ohio, United States
Options Health Research
🇺🇸Tulsa, Oklahoma, United States
US Digestive Health
🇺🇸Wyomissing, Pennsylvania, United States
Penn State Milton S. Hershey Medical Center
🇺🇸Hershey, Pennsylvania, United States
Digestive Disease Associates
🇺🇸Wyomissing, Pennsylvania, United States
Tianjin Second People's Hospital
🇨🇳Tianjin Shi, China
ObjectiveHealth-Columbia Digestive Health Research
🇺🇸Columbia, South Carolina, United States
Palmetto Clinical Research
🇺🇸Summerville, South Carolina, United States
ClinSearch, LLC
🇺🇸Chattanooga, Tennessee, United States
Premier Medical Group
🇺🇸Clarksville, Tennessee, United States
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
Texas Clinical Research Institute, LLC
🇺🇸Arlington, Texas, United States
IMA Clinical Research Austin
🇺🇸Austin, Texas, United States
Velocity Clinical Research, Austin
🇺🇸Austin, Texas, United States
South Texas Research Institute-Brownsville-68426
🇺🇸Brownsville, Texas, United States
Velocity Clinical Research-Dallas-69170
🇺🇸Dallas, Texas, United States
Zenos Clinical Research
🇺🇸Dallas, Texas, United States
North Texas Research Institute - Dallas
🇺🇸Dallas, Texas, United States
Baylor Scott & White Research Institute
🇺🇸Dallas, Texas, United States
GI Alliance
🇺🇸Dallas, Texas, United States
Soma Clinical Trials
🇺🇸Denison, Texas, United States
South Texas Research Institute-Edinburg-67012
🇺🇸Edinburg, Texas, United States
Care United Research
🇺🇸Forney, Texas, United States
Pinnacle Clinical Research
🇺🇸San Antonio, Texas, United States
Ben Taub General Hospital
🇺🇸Houston, Texas, United States
Houston Research Institute
🇺🇸Houston, Texas, United States
Biopharma Informatic, Inc. Research Center
🇺🇸Houston, Texas, United States
Epic Clinical Research
🇺🇸Lewisville, Texas, United States
Biopharma Informatic LLC
🇺🇸McAllen, Texas, United States
Centex Studies, Inc.-Mcallen-66872
🇺🇸McAllen, Texas, United States
Office of Rukan Daccak, MD
🇺🇸Pasadena, Texas, United States
Brooke Army Medical Center
🇺🇸San Antonio, Texas, United States
Pinnacle Clinical Research, LLC
🇺🇸San Antonio, Texas, United States
Clinical Trials of Texas, LLC
🇺🇸San Antonio, Texas, United States
HASresearch
🇺🇸San Antonio, Texas, United States
ObjectiveHealth-Digestive Health Research of North Texas
🇺🇸Wichita Falls, Texas, United States
Physicians' Research Options. LLC
🇺🇸Draper, Utah, United States
GI Select Health Research LLC
🇺🇸Richmond, Virginia, United States
Velocity Clinical Research-Seattle-69881
🇺🇸Seattle, Washington, United States
Velocity Clinical Research-Spokane-69716
🇺🇸Spokane, Washington, United States
CINME Centro de Investigaciones Metabólicas
🇦🇷Buenos Aires, Argentina
HOP Henri-Mondor
🇫🇷Île-de-France, France
IDIM - Instituto de Diagnostico e Investigaciones Metabolicas
🇦🇷Caba, Argentina
Centro de Investigaciones y Prevencion Cardiovascular CIPREC
🇦🇷Ciudad Autonoma de Buenos Aire, Argentina
Buenos Aires Macula S.A.
🇦🇷Ciudad Autónoma de Buenos Aires, Argentina
Centro Médico Saavedra
🇦🇷Ciudad Autónoma de Buenos Aires, Argentina
Hospital El Cruce
🇦🇷Florencio Varela, Argentina
Hospital Universitario Austral
🇦🇷Pilar, Argentina
DIM Clinica Privada
🇦🇷Ramos Mejía, Argentina
Concord Repatriation General Hospital
🇦🇺Concord, New South Wales, Australia
Nepean Hospital
🇦🇺Kingswood, New South Wales, Australia
Liverpool Hospital
🇦🇺Liverpool, New South Wales, Australia
Westmead Hospital
🇦🇺Westmead, New South Wales, Australia
Gold Coast University Hospital
🇦🇺Southport, Queensland, Australia
Monash Health
🇦🇺Clayton, Victoria, Australia
Austin Health
🇦🇺Heidelberg, Victoria, Australia
Royal Melbourne Hospital
🇦🇺Parkville, Victoria, Australia
Royal Perth Hospital
🇦🇺Perth, Western Australia, Australia
Medical University of Graz State Hospital - University Hospital Graz
🇦🇹Graz, Austria
KH der Barmherzigen Schwestern Linz
🇦🇹Linz, Austria
AKH - Medical University of Vienna
🇦🇹Vienna, Austria
Klinikum Wels - Grieskirchen GmbH
🇦🇹Wels, Austria
Hospital Hietzing
🇦🇹Wien, Austria
ULB Hopital Erasme
🇧🇪Anderlecht, Belgium
Edegem - UNIV UZ Antwerpen
🇧🇪Edegem, Belgium
Ziekenhuis Oost-Limburg - Campus Sint-Jan
🇧🇪Genk, Belgium
Centre Hospitalier Universitaire de Liège
🇧🇪Liège, Belgium
Roeselare - HOSP AZ Delta
🇧🇪Roeselare, Belgium
Hospital Universitário João de Barros Barreto
🇧🇷Belem, Brazil
Hospital das Clinicas da FMUSP
🇧🇷Cerqueira Cesar, Brazil
Associação Hospitalar Moinhos de Vento
🇧🇷Porto Alegre, Brazil
Universidade Federal do Rio Grande do Sul
🇧🇷Porto Alegre, Brazil
Hospital de Base - Fac Med de Sao Jose do Rio Preto
🇧🇷Sao Jose Do Rio Preto, Brazil
MHAT Sv. Ivan Rilski EOOD
🇧🇬Gorna Oryahovitsa, Bulgaria
Multi-profile Hospital For Active Treatment-Uni Hospital Ltd.
🇧🇬Panagyurishte, Bulgaria
Acibadem City Clinic University multi-profile Hospital for active treatment Tokuda Hospital
🇧🇬Sofia, Bulgaria
Diagnostic Consultative Center Alexandrovska
🇧🇬Sofia, Bulgaria
University Multiprofile Hospital for Active Treatment St. Ivan Rilski EAD
🇧🇬Sofia, Bulgaria
Medical Military Academy MHAT Sofia
🇧🇬Sofia, Bulgaria
Medical Center New Rehabilitation Center EOOD
🇧🇬Stara Zagora, Bulgaria
University of Calgary
🇨🇦Calgary, Alberta, Canada
Viable Clinical Research
🇨🇦Bridgewater, Nova Scotia, Canada
Toronto Liver Centre
🇨🇦Toronto, Ontario, Canada
McGill University Health Centre (MUHC)
🇨🇦Montreal, Quebec, Canada
Diex Recherche Québec
🇨🇦Quebec, Canada
Edificio Fleming
🇨🇱La Serena, Chile
Centro de Investigaciones Médicas UC
🇨🇱Santiago, Chile
Centro de Investigaciones Clinicas Viña del Mar
🇨🇱Viña del Mar, Chile
Beijing Ditan Hospital Capital Medical University
🇨🇳Beijing, China
Beijing Tsinghua Changgung Hospital
🇨🇳Beijing, China
Peking University People's Hospital
🇨🇳Beijing, China
Beijing Friendship Hospital
🇨🇳Beijing, China
Beijing Youan Hospital, Capital Medical University
🇨🇳Beijing, China
The First Hospital of Jilin University
🇨🇳Changchun, China
Hunan Provincial People's Hospital
🇨🇳Changsha, China
Changzhou Third People's Hospital
🇨🇳Changzhou Shi, China
West China Hospital of Sichuan University
🇨🇳Chengdu, China
Chongqing Three Gorges Central Hospital
🇨🇳Chongqing, China
The First People's Hospital of Foshan
🇨🇳Foshan, China
The First Affiliated Hospital of Fujian Medical University
🇨🇳Fuzhou, China
Fujian Medical University Union Hospital
🇨🇳Fuzhou, China
Guangzhou First People's Hospital
🇨🇳Guangzhou, China
Guangzhou Eighth People's Hospital,Guangzhou Medical University
🇨🇳Guangzhou, China
The First Affiliated Hospital,Sun Yat-sen University
🇨🇳Guangzhou, China
NanFang Hosptial
🇨🇳Guangzhou, China
The third affiliated hospital of Sun Yat-Sen University
🇨🇳Guangzhou, China
Guizhou People's Hospital
🇨🇳Guiyang, China
The First Affiliated Hospital, Zhejiang University
🇨🇳Hangzhou, China
Zhejiang Hospital
🇨🇳Hangzhou, China
The Affiliated Hospital of Hangzhou Normal University
🇨🇳Hangzhou, China
Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine
🇨🇳Hangzhou, China
The First hospital of Jiaxing
🇨🇳Jiaxing, China
Liaocheng People's Hospital
🇨🇳Liaocheng, China
The First Affiliated Hospital of Nanchang University
🇨🇳Nanchang, China
The Second Affiliated Hospital to Nanchang University
🇨🇳Nanchang, China
The Second Hospital of Nanjing
🇨🇳Nanjing, China
Nanjing Drum Tower Hospital
🇨🇳Nanjing, China
Nanjing Jiangning Hospital
🇨🇳Nanjing, China
Ningbo Second Hospital
🇨🇳Ningbo, China
Pingxiang People's Hospital
🇨🇳Pingxiang, China
Qingdao Municipal Hospital
🇨🇳Qingdao, China
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
🇨🇳Shanghai, China
Shanghai General Hospital
🇨🇳Shanghai, China
Shanghai East Hospital
🇨🇳Shanghai, China
Renji Hospital Shanghai Jiaotong Univesrity School of Medicine
🇨🇳Shanghai, China
Shanghai Public Health Clinical Center
🇨🇳Shanghai, China
The Sixth People's Hospital of Shenyang
🇨🇳Shenyang, China
Peking University Shenzhen Hospital
🇨🇳Shenzhen, China
The Fifth People's Hospital of Suzhou
🇨🇳Suzhou, China
Tianjin Third Central Hospital
🇨🇳Tianjin, China
Tongji Hospital Affiliated Tongji Medical College Huazhong University of S & T
🇨🇳Wuhan, China
Renmin Hospital of Wuhan University
🇨🇳Wuhan, China
Second Affiliated Hospital of Xi'an JiaoTong University
🇨🇳Xi'An, China
First Affiliated Hospital of Xi'an JiaoTong University
🇨🇳Xi'an, China
Affiliated Hospital, Xuzhou Medical college
🇨🇳Xuzhou, China
Yanbian University Hospital
🇨🇳Yanji, China
General Hospital of Ningxia Medical University
🇨🇳Yinchuan, China
Yueyang Central Hospital
🇨🇳Yueyang, China
The First Affiliated Hosptial of Wenzhou Medical University
🇨🇳Zhejiang, China
Sixth People's Hospital of Zhengzhou
🇨🇳Zhengzhou, China
The Third People's Hospital of Zhenjiang
🇨🇳Zhenjiang, China
Regional Hospital Liberec
🇨🇿Liberec, Czechia
RESEARCH SITE s.r.o.
🇨🇿Plzen, Czechia
General Faculty Hospital, Prague
🇨🇿Praha 2, Czechia
Hopitaux Universitaires Paris Nord Val de Seine - Hopital Beaujon
🇫🇷Clichy-Sous-Bois, France
HOP Dijon-Bourgogne
🇫🇷Côte-d'Or, France
HOP Rangueil
🇫🇷Haute-Garonne, France
Centre Hospitalier De Versailles
🇫🇷Le Chesnay, France
HOP Croix-Rousse
🇫🇷Lyon, France
CHU D´Angers - Hôpital Larrey
🇫🇷Maine-et-Loire, France
HOP Claude Huriez
🇫🇷Nord-Pas-de-Calais, France
CHU - Groupe Hospitalier Pitié-Salpétrière
🇫🇷Paris, France
HOP Lyon Sud
🇫🇷Rhône, France
Ltd "Health"
🇬🇪Batumi, Georgia
ISR-GEO Med Res Clin Healthycore
🇬🇪Tbilisi, Georgia
Charite Universitätsmedizin Berlin KöR
🇩🇪Berlin, Germany
Universitätsklinikum Knappschaftskrankenhaus Bochum GmbH
🇩🇪Bochum, Germany
Technische Universität Dresden
🇩🇪Dresden, Germany
Universitätsklinikum Frankfurt
🇩🇪Frankfurt, Germany
Universitätsklinikum Freiburg
🇩🇪Freiburg, Germany
Universitätsklinikum Heidelberg
🇩🇪Heidelberg, Germany
Universität des Saarlandes
🇩🇪Homburg, Germany
Universitätsklinikum Köln (AöR)
🇩🇪Köln Lindenthal, Germany
Universitätsklinikum Schleswig-Holstein, Campus Lübeck
🇩🇪Lübeck, Germany
Otto-von-Guericke-Universität Magdeburg
🇩🇪Magdeburg, Germany
BAPS Pramukh Swami Hospital
🇮🇳Surat, India
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
🇩🇪Mainz, Germany
Universitätsklinikum Mannheim GmbH
🇩🇪Mannheim, Germany
Universitätsklinikum Münster
🇩🇪Münster, Germany
Universitätsklinikum Tübingen
🇩🇪Tübingen, Germany
Universitätsklinikum Ulm
🇩🇪Ulm, Germany
St. Josefs-Hospital, Wiesbaden
🇩🇪Wiesbaden, Germany
Universitätsklinikum Würzburg AÖR
🇩🇪Würzburg, Germany
Dr. Rethy Pal Hospital
🇭🇺Bekescsaba, Hungary
Obuda Health Center
🇭🇺Budapest, Hungary
Semmelweis Egyetem Sebeszeti, Transzplantacios es Gasztroenterologiai Klinika
🇭🇺Budapest, Hungary
Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet
🇭🇺Budapest, Hungary
Aryav Superspeciality Hospital
🇮🇳Ahemdabad, India
Institute of Post Graduate Medical Education and Research
🇮🇳Chandigarh, India
Osmania Medical College & Hospital
🇮🇳Hyderabad, India
SR Kalla Memorial Hospital
🇮🇳Jaipur, India
ManglamPlus Medicity Hospital
🇮🇳Jaipur, India
G S V M, Kanpur
🇮🇳Kanpur, India
Atharva Multispecialty Hospital and research Centre
🇮🇳Lucknow, India
Midas Multispeciality Hospital Pvt Ltd
🇮🇳Nagpur, India
All India Institute of Medical Sciences
🇮🇳New Delhi, India
Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
🇮🇳Rohtak, India
Yashoda Hospitals - Secunderabad
🇮🇳Secunderabad, India
Surat Institute of Digestive Sciences
🇮🇳Surat, India
Gujarat Gastro and Vascular Hospital
🇮🇳Surat, India
Policlinico S. Orsola-Malpighi
🇮🇹Bologna, Italy
Az.Osp. Universitaria "Ospedali Riuniti"
🇮🇹Foggia, Italy
Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico
🇮🇹Milano, Italy
Università degli Studi di Genova
🇮🇹Modena, Italy
Policlinico "Paolo Giaccone"
🇮🇹Palermo, Italy
Fondazione Policlinico Universitario Campus Bio-medico
🇮🇹Roma, Italy
Istituto Clinico Humanitas
🇮🇹Rozzano, Italy
AO Città della Salute e Scienza
🇮🇹Turin, Italy
Fujita Health University Hospital
🇯🇵Aichi, Toyoake, Japan
The University of Tokyo Hospital
🇯🇵Bunkyo-ku, Japan
National Center for Global Health and Medicine Kohnodai Hospital
🇯🇵Chiba, Ichikawa, Japan
Chiba University Hospital
🇯🇵Chiba, Japan
Ehime University Hospital
🇯🇵Ehime, Toon, Japan
Fukuiken Saiseikai Hospital
🇯🇵Fukui, Fukui, Japan
National Hospital Organization Kyushu Medical Center
🇯🇵Fukuoka, Fukuoka, Japan
Kurume University Hospital
🇯🇵Fukuoka, Kurume, Japan
Gifu Municipal Hospital
🇯🇵Gifu, Gifu, Japan
Ogaki Municipal Hospital
🇯🇵Gifu, Ogaki, Japan
Nagano Municipal Hospital
🇯🇵Hanishina-gun, Japan
Hiroshima University Hospital
🇯🇵Hiroshima, Hiroshima, Japan
Sapporo Kosei General Hospital
🇯🇵Hokkaido, Sapporo, Japan
Japan Community Health Care Organization Hokkaido Hospital
🇯🇵Hokkaido, Sapporo, Japan
Hyogo College of Medicine Hospital
🇯🇵Hyogo, Nishinomiya, Japan
Tokyo Medical University Ibaraki Medical Center
🇯🇵Ibaraki, Inashiki-gun, Japan
Tokai University Hospital
🇯🇵Isehara, Japan
Kanazawa University Hospital
🇯🇵Ishikawa, Kanazawa, Japan
Shimane University Hospital
🇯🇵Izumo, Japan
Kagoshima University Hospital
🇯🇵Kagoshima, Kagoshima, Japan
Shin-yurigaoka General Hospital
🇯🇵Kanagawa, Kawasaki, Japan
St. Marianna University Hospital
🇯🇵Kanagawa, Kawasaki, Japan
Kagawa University Hospital
🇯🇵Kita-gun, Japan
Kobe University Hospital
🇯🇵Kobe, Japan
Kumamoto University Hospital
🇯🇵Kumamoto, Kumamoto, Japan
Kumamoto Shinto General Hospital
🇯🇵Kumamoto, Kumamoto, Japan
National Hospital Organization Kure Medical Center and Chugoku Cancer Center
🇯🇵Kure, Japan
University Hospital Kyoto Prefectural University of Medicine
🇯🇵Kyoto, Kyoto, Japan
Mie University Hospital
🇯🇵Mie, Tsu, Japan
University of Miyazaki Hospital
🇯🇵Miyazaki, Miyazaki, Japan
Shinshu University Hospital
🇯🇵Nagano, Matsumoto, Japan
Nagasaki Medical Center
🇯🇵Nagasaki, Omura, Japan
Nara Medical University Hospital
🇯🇵Nara, Kashihara, Japan
Niigata University Medical and Dental Hospital
🇯🇵Niigata, Niigata, Japan
Oita Cardiovascular Hospital
🇯🇵Oita, Japan
Osaka City University Hospital
🇯🇵Osaka, Osaka, Japan
Suita Hospital
🇯🇵Osaka, Suita, Japan
The University of Osaka Hospital
🇯🇵Osaka, Suita, Japan
Saga University Hospital
🇯🇵Saga, Saga, Japan
Osaka Rosai Hospital
🇯🇵Sakai, Japan
Seichokai Bell Land General Hospital
🇯🇵Sakai, Japan
Sendai Tokushukai Hospital
🇯🇵Sendai-shi, Japan
JCHO Shimonoseki Medical Center
🇯🇵Shimonoseki, Japan
Tokyo Medical University Hospital
🇯🇵Tokyo, Bunkyo-ku, Japan
Hamamatsu University Hospital
🇯🇵Shizuoka, Hamamatsu, Japan
Juntendo University Shizuoka Hospital
🇯🇵Shizuoka, Izunokuni, Japan
National Hospital Organization Takasaki General Medical Center
🇯🇵Takasaki, Japan
Nippon Medical School Hospital
🇯🇵Tokyo, Bunkyo-ku, Japan
Toranomon Hospital
🇯🇵Tokyo, Minato-ku, Japan
Japanese Red Cross Musashino Hospital
🇯🇵Tokyo, Musashino, Japan
Wakayama Medical University Hospital
🇯🇵Wakayama, Japan
Yokohama City University Hospital
🇯🇵Yokohama, Japan
The Speciality Hospital (TSH)
🇯🇴Amman, Jordan
Jordan University Hospital
🇯🇴Jordan, Jordan
Soon Chun Hyang University Hospital Bucheon
🇰🇷Bucheon-Si, Korea, Republic of
Pusan National Univ. Hosp
🇰🇷Busan, Korea, Republic of
Inha University Hospital
🇰🇷Incheon, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Chung-Ang University Hospital
🇰🇷Seoul, Korea, Republic of
SMG-SNU Boramae Medical Center
🇰🇷Seoul, Korea, Republic of
Korea University Guro Hospital
🇰🇷Seoul, Korea, Republic of
Yonsei University Wonju Severance Christian Hospital
🇰🇷Wonju-Si, Korea, Republic of
Centro de Investigacion Clinica del Pacifico (CICPA)
🇲🇽Acapulco de Juarez, Mexico
Clinicos Asociados BOCM SC
🇲🇽Benito Juarez, Mexico, Mexico
Centro de Investigación y Gastroenterología
🇲🇽Mexico City, Mexico
Instituto de Diabetes, Obesidad y Nutrición S.C.
🇲🇽Cuautla, Mexico
Medical Care and Research
🇲🇽Merida, Mexico
Sociedad de Metabolismo y Corazón S.C.
🇲🇽Veracruz, Mexico
Centro de Alta Especialidad del Estado de Veracruz
🇲🇽Xalapa, Mexico
Amsterdam UMC Locatie VUMC
🇳🇱Amsterdam, Netherlands
Radboud Universitair Medisch Centrum
🇳🇱Nijmegen, Netherlands
Erasmus Medisch Centrum
🇳🇱Rotterdam, Netherlands
Franciscus Gasthuis
🇳🇱Rotterdam, Netherlands
Tweesteden Ziekenhuis, locatie Tilburg
🇳🇱Tilburg, Netherlands
Ziekenhuis Bernhoven
🇳🇱Uden, Netherlands
Universitair Medisch Centrum Utrecht
🇳🇱Utrecht, Netherlands
New Zealand Clinical Research (NZCR)
🇳🇿Grafton, Auckland, New Zealand
Middlemore Hospital
🇳🇿Papatoetoe, Auckland, New Zealand
Christchurch Hospital
🇳🇿Christchurch, Canterbury, New Zealand
Krakowskie Centrum Medyczne Sp. z o.o.
🇵🇱Krakow, Poland
FutureMeds Lodz
🇵🇱Lodz, Poland
Uniwersytecki Szpital Kliniczny Nr 1 W Lublinie
🇵🇱Lublin, Poland
ID Clinic
🇵🇱Myslowice, Poland
FutureMeds Warszawa Centrum
🇵🇱Warsaw, Poland
Bodyclinic
🇵🇱Warszawa, Poland
EMC Instytut Medyczny S.A.-Wroclaw-70301
🇵🇱Wroclaw, Poland
FutureMeds Wroclaw
🇵🇱Wrocław, Poland
Santa Familia PTG Łódź
🇵🇱Łódź, Poland
Klinical Investigations Group, LLC
🇵🇷San Juan, Puerto Rico
Latin Clinical Trial Center
🇵🇷San Juan, Puerto Rico
FDI Clinical Research
🇵🇷San Juan, Puerto Rico
Hightech Medical Services
🇷🇴Bucuresti, Romania
Cluj Napoca Clinical County Hospital
🇷🇴Cluj-Napoca, Romania
Regional Institute of Gastroenterology Hepatology "Prof. Dr. O. Fodor"
🇷🇴Cluj-Napoca, Romania
Gastromedica Srl
🇷🇴Iasi, Romania
King Faisal Specialist Hospital and Research Center
🇸🇦Ramah, Saudi Arabia
King Abdulaziz Medical City, National Guard Health Affairs
🇸🇦Riyadh, Saudi Arabia
National University Hospital
🇸🇬Singapore, Singapore
Singapore General Hospital
🇸🇬Singapore, Singapore
Changi General Hospital
🇸🇬Singapore, Singapore
Practice Dr Naeem Moosa
🇿🇦Johannesburg, South Africa
Inspired GI Care
🇿🇦Plumstead, South Africa
Hospital A Coruña
🇪🇸A Coruña, Spain
Hospital Vall d'Hebron
🇪🇸Barcelona, Spain
Hospital Universitario Reina Sofía-Córdoba-40500
🇪🇸Córdoba, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Hospital Puerta de Hierro
🇪🇸Majadahonda, Spain
Complexo Hospitalario Universitario de Pontevedra
🇪🇸Pontevedra, Spain
Hospital Clínico de Santiago
🇪🇸Santiago de Compostela, Spain
University Hospital Bern/Inselspital Bern
🇨🇭Bern, Switzerland
Hopitaux Universitaires de Geneve (HUG)
🇨🇭Geneve, Switzerland
Clinica Luganese Moncucco
🇨🇭Lugano, Switzerland
University Hospital Zurich
🇨🇭Zuerich, Switzerland
Chang-Hua Christian Hospital
🇨🇳Changhua City, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳Kaohsuing City, Taiwan
Chung Shan Medical University Hospital
🇨🇳Taichung City, Taiwan
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
National Cheng Kung University Hospital
🇨🇳Tainan City, Taiwan
Chi Mei Medical Center
🇨🇳Tainan City, Taiwan
National Taiwan University Hospital
🇨🇳Taipei City, Taiwan
Taipei Medical University Hospital
🇨🇳Taipei City, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei City, Taiwan
Chang Gung Medical Foundation (CGMF) - Linkou Bran
🇨🇳Taoyuan City, Taiwan
Ankara Üniversitesi Tıp Fakültesi Hastanesi
🇹🇷Ankara, Turkey
Gazi Universitesi Tip Fakultesi
🇹🇷Ankara, Turkey
Memorial Bahçelievler Hospital
🇹🇷Bahcelievler, Turkey
Uludag University Medicine Faculty Departmant of Dermatology
🇹🇷Bursa, Turkey
Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi
🇹🇷Fatih, Turkey
Koc Universitesi Hastanesi
🇹🇷Istanbul, Turkey
Ege Universitesi Tip Fakultesi
🇹🇷Izmir, Turkey
Recep Tayyip Erdogan Universitesi Egitim ve Arastirma Hastanesi
🇹🇷Rize, Turkey
Aberdeen Royal Infirmary
🇬🇧Aberdeen, United Kingdom
Panthera Biopartners - York
🇬🇧Acomb, York, United Kingdom
University Hospitals Birmingham NHS Foundation Trust
🇬🇧Birmingham, United Kingdom
Velocity Clinical Research, Bristol
🇬🇧Bristol, United Kingdom
Panthera Biopartners - North London
🇬🇧Enfield, United Kingdom
Frimley Health NHS Foundation Trust - Frimley Park Hospital
🇬🇧Frimley, United Kingdom
Panthera Biopartners - Glasgow
🇬🇧Glasgow, United Kingdom
Royal Surrey NHS Foundation Trust - St Luke's Cancer Centre
🇬🇧Guildford, United Kingdom
Aintree University Hospital
🇬🇧Liverpool, United Kingdom
Elpida Clinical Trials - St Andrews Medical Practice
🇬🇧London, United Kingdom
Royal Free Hospital
🇬🇧London, United Kingdom
King's College Hospital
🇬🇧London, United Kingdom
Chelsea and Westminster Hospital NHS Foundation Trust - Chelsea and Westminster Hospital
🇬🇧London, United Kingdom
St George's University Hospitals NHS Foundation Trust
🇬🇧London, United Kingdom
Imperial College Healthcare NHS Trust
🇬🇧London, United Kingdom
Accellacare North London
🇬🇧Northwood, United Kingdom
Nottingham University Hospitals NHS Trust
🇬🇧Nottingham, United Kingdom
Accellacare South London
🇬🇧Orpington, United Kingdom
Oxford University Hospitals NHS Foundation Trust
🇬🇧Oxford, United Kingdom
Portsmouth Hospitals University NHS Trust - Queen Alexandra Hospital
🇬🇧Portsmouth, United Kingdom
Panthera Biopartners - Preston
🇬🇧Preston, United Kingdom
Panthera Biopartners - Manchester
🇬🇧Rochdale, United Kingdom
Panthera Biopartners - Sheffield
🇬🇧Sheffield, United Kingdom
Elpida St George's Medical Centre
🇬🇧Wallasey, United Kingdom