A pilot study of high dose allopurinol in the treatment of gout:

isa Stamp0 个研究点目标入组 100 人开始时间: 2006年7月3日最近更新: 2020年1月13日

适应症

试验速览

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•1. Patients fulfil the diagnostic criteria of gout (Wallace, Robinson et al. 1977) which are as follows Clinical diagnosis of gout requires either A, B, or C to be metA. The presence of characteristic urate crystals in the joint fluidB. A tophus proved to contain urate crystals by chemical means or polarised light microscopyC. The presence of 6 of the following 12 clinical laboratory, and x-ray phenomenaI. Maximum inflammation developed within one dayII. More than one attack of acute arthritisIII. Attack of monoarthritisIV. Redness observed over the affected joint(s)V. First metatarsophalangeal joint painful or swollenVI. Unilateral first metatarsophalangeal joint attackVII. Unilateral attack involving tarsal jointVIII. Suspected tophusIX. HyperuricaemiaX. Asymmetric swelling within a joint XI. Subcortical cysts without erosionsXII. Negative culture of joint fluid for microorganisms during attack of joint inflammation. 2. Subjects are willing and able to participate in the study and from whom written informed consent has been obtained.

•1. History of adverse effects with use of allopurinol.2. Patients currently taking azathioprine3. Patients with a solid organ transplant (eg kidney, liver or heart transplant)4. Presence of chronic infection or other severe concomitant medical illness or psychiatric disease.5. Pregnant or breast-feeding females and female subjects of child bearing age who are not practising medically approved methods of contraception.6. HIV positive patients.7. History of drug abuse that would interfere with the ability to comply with the study protocol.8. Patients with active, concomitant malignancies.

发起方

isa Stamp