Autologous PRP treatment for refractory thin endometrium to enhance pregnancy and live birth rate

Not Applicable

Recruiting

• Conditions: Pregnancy, childbirth and the puerperium

• Registration Number: KCT0003385
• Lead Sponsor: Bundang CHA General Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 11 March 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

(a) age of 20?45 years at the time of enrollment, (b) endometrial thickness (EMT) of <7 mm on the human chorionic gonadotropin (hCG) administration day in fresh ET cycles or on the end of estrogen priming day in frozen ET cycles in all of the previous cycles, (c) two or more failed IVF cycles, (d) more than two cycles of previous therapy for increasing the EMT, such as, hysteroscopic adhesiolysis following hormone replacement therapy, high dose estradiol valerate, transvaginal sildenafil administration, or pentoxifyilline combination with vitamin E, (e) frozen embryo available for ET, and (f) informed consent form signed.

Exclusion Criteria

(a) hematologic disorders, hemoglobin level of <9.0 g/dL or platelet count of <100,000/µL, (b) auto-immune disease, (c) chromosomal abnormality in the patient or spouse, (d) peripheral NK cell proportion of =12%, (e) body mass index (BMI) of =30 kg/m2, and (f) uncontrolled endocrine or other medical conditions, such as prolactinemia or thyroid diseases

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ive birth rate

Secondary Outcome Measures

Name	Time	Method
clinical pregnancy day;Emdometrial thickness increment