The role of the TGF-ß/Smads signaling pathway in the osteogenic degeneration of cervical intervertebral disc in patients with cervical spondylosis undergoing surgical treatment

Dongzhimen Hospital, Beijing University of Chinese Medicine0 个研究点开始时间: 待定最近更新: 2023年2月20日

研究概览

暂无简介。

•1. The patient was diagnosed as cervical spondylosis based on clinical and radiological evidence.
•2. Surgery for the first time was performed after at least 6 weeks conservative treatment, which was ineffective;
•3. The surgical methods were either artificial cervical disc replacement (ACDR) or anterior cervical discectomy and fusion (ACDF).

•1. The cervical degeneration was serious, and the loss of intervertebral height was more than 80% of the adjacent normal segments.
•2. Sufficient disc samples could not be obtained during operation.
•3. Operative contraindications were found, such as poor cardiopulmonary function and intolerance to the surgery.
•4. The patient had a history of neck injury or related surgery.
•5. There was active hemorrhage or infection history of the patient.
•6. There was a history of fracture, tumor, tuberculosis and other tissue-invasive diseases in the cervical spine.

发起方

Dongzhimen Hospital, Beijing University of Chinese Medicine