Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty

Phase 4

• Conditions: Pain; Complications
• Interventions: Procedure: Local analgesic; Procedure: Nerve Block; Procedure: Intravenous analgesic; Drug: ropivacaine; Drug: opioid

• Registration Number: NCT02094339
• Lead Sponsor: Guangzhou General Hospital of Guangzhou Military Command

Brief Summary

Postoperative pain after total knee arthroplasty (TKA) can be difficult to manage and may delay recovery. There are multimodal postoperative pain management after TKA, including intravenous opioids, epidural analgesia, peripheral nerve blocks or periarticular infiltration with local anesthetics. All of these treatments may lead to side effects such as nausea, headache, hypotension, urinary retention, partial motor block and infection of the knee. Therefore the investigators will compare three methods of postoperative analgesic after TKA by their efficiency and complication.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-03
• Study First Submitted: 2014-03-19
• Study First Submitted QC: 2014-03-20
• Study First Posted: 2014-03-21
• Status Verified: 2015-03
• Last Update Submitted: 2015-03-11
• Last Update Posted: 2015-03-12
• Primary Completion: 2016-06
• Study Completion: 2016-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

1. Patients of American Association of anesthetists（ASA）Grade 1、2 or 3
2. Aged between 18 and 85 years
3. Undergoing elective total knee replacement

Exclusion Criteria

1. Mental illness can not match
2. Nerve block, epidural anesthesia contraindicated
3. People who have Slow-type arrhythmias
4. History of chronic headaches and long-term use of analgesic drugs
5. People who were postoperative consciousness, language or hearing impaired

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Local analgesic	Local analgesic	This group uses local analgesia infusion pump of 0.2% ropivacaine 360ml through periarticular infiltration for postoperative analgesia.
Local analgesic	ropivacaine	This group uses local analgesia infusion pump of 0.2% ropivacaine 360ml through periarticular infiltration for postoperative analgesia.
Nerve Block	Nerve Block	People in this group will receive a postoperative pain management by continuous lumbar plexus block with 0.2% ropivacaine.
Nerve Block	ropivacaine	People in this group will receive a postoperative pain management by continuous lumbar plexus block with 0.2% ropivacaine.
Intravenous analgesic	Intravenous analgesic	This group is treated with intravenous electronic analgesia pump infusion of flurbiprofen axetil 250mg,palonosetron 0.5mg,pentazocine 240mg.dezocine 30mg.
Intravenous analgesic	opioid	This group is treated with intravenous electronic analgesia pump infusion of flurbiprofen axetil 250mg,palonosetron 0.5mg,pentazocine 240mg.dezocine 30mg.

Primary Outcome Measures

Name	Time	Method
pain	72 hours postoperation	Up to 72 hours after operation,postoperative pain visual analogue scale(VAS) scores are used to evaluate the level of pain.

Secondary Outcome Measures

Name	Time	Method
complication	72 hours postoperation	Investigators document the incidence of nausea,vomiting,headache,urinary retention and et al.
sedation	72 hours postoperation	At 2, 4, 6, 12, 24, 36, 48,72 hours after operation,sedation OAA/S scores are used to evaluate the level of sedation.

Trial Locations

Locations (1)

Guangzhou Military Region General Hospital, Department of Anesthesiology; 🇨🇳 Guangzhou, Guangdong, China