Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty :a Randomized Clinical Trial
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- pain
研究概览
简要总结
Postoperative pain after total knee arthroplasty (TKA) can be difficult to manage and may delay recovery. There are multimodal postoperative pain management after TKA, including intravenous opioids, epidural analgesia, peripheral nerve blocks or periarticular infiltration with local anesthetics. All of these treatments may lead to side effects such as nausea, headache, hypotension, urinary retention, partial motor block and infection of the knee. Therefore the investigators will compare three methods of postoperative analgesic after TKA by their efficiency and complication.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients of American Association of anesthetists（ASA）Grade 1、2 or 3
- •Aged between 18 and 85 years
- •Undergoing elective total knee replacement
排除标准
- •Mental illness can not match
- •Nerve block, epidural anesthesia contraindicated
- •People who have Slow-type arrhythmias
- •History of chronic headaches and long-term use of analgesic drugs
- •People who were postoperative consciousness, language or hearing impaired
研究组 & 干预措施
Local analgesic
This group uses local analgesia infusion pump of 0.2% ropivacaine 360ml through periarticular infiltration for postoperative analgesia.
干预措施: Local analgesic (Procedure)
Local analgesic
This group uses local analgesia infusion pump of 0.2% ropivacaine 360ml through periarticular infiltration for postoperative analgesia.
干预措施: ropivacaine (Drug)
Nerve Block
People in this group will receive a postoperative pain management by continuous lumbar plexus block with 0.2% ropivacaine.
干预措施: Nerve Block (Procedure)
Nerve Block
People in this group will receive a postoperative pain management by continuous lumbar plexus block with 0.2% ropivacaine.
干预措施: ropivacaine (Drug)
Intravenous analgesic
This group is treated with intravenous electronic analgesia pump infusion of flurbiprofen axetil 250mg,palonosetron 0.5mg,pentazocine 240mg.dezocine 30mg.
干预措施: Intravenous analgesic (Procedure)
Intravenous analgesic
This group is treated with intravenous electronic analgesia pump infusion of flurbiprofen axetil 250mg,palonosetron 0.5mg,pentazocine 240mg.dezocine 30mg.
干预措施: opioid (Drug)
结局指标
主要结局
pain
时间窗: 72 hours postoperation
Up to 72 hours after operation,postoperative pain visual analogue scale(VAS) scores are used to evaluate the level of pain.
次要结局
- complication(72 hours postoperation)
- sedation(72 hours postoperation)
研究者
bo xu
associate chief physician
Guangzhou General Hospital of Guangzhou Military Command