Evaluating the Prevalence and Implications of Obstructive Sleep Apnea Among Somali-Americans: A Translational Research Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obstructive Sleep Apnea
- Sponsor
- Mayo Clinic
- Enrollment
- 600
- Locations
- 1
- Primary Endpoint
- To assess the prevalence of obstructive sleep apnea
- Status
- Recruiting
- Last Updated
- 7 months ago
Overview
Brief Summary
The investigators seek to advance the understanding of obstructive sleep apnea as it relates to different ethnic origins as well as sex differences. The investigators will compare Somali patients with known obstructive sleep apnea (OSA) to individuals without OSA, and to individuals of other ethnic/racial origins to determine the risk factors (genetic and/or physiologic) associated with developing cardiovascular diseases. This will help the investigators to understand the unique sleep pathology of individuals of African descent.
Detailed Description
Participants can be healthy volunteers or volunteers diagnosed with obstructive sleep apnea. All patients may undergo a sleep study (i.e. hospital or home-based), physical examination, questionnaires, blood and urine samples, ultrasound scan of the heart and brachial artery in the arm, CT scan, DEXA scan, paced breathing test, cardiopulmonary test and chemo-sensitivity test.
Investigators
Virend Somers, MD, PhD
Principal Investigator
Mayo Clinic
Eligibility Criteria
Inclusion Criteria
- •Self-identify as Somali, African, Asian, and European descent.
- •Adult males and females who are older than 18 years of age.
Exclusion Criteria
- •Minors under 18 years or adults over 100 years
- •Positive pregnancy
Outcomes
Primary Outcomes
To assess the prevalence of obstructive sleep apnea
Time Frame: 10 years
Measure the apnea-hypopnea index (AHI) to determine burden of obstructive sleep apnea. Based on the AHI, sleep apnea will be diagnosed if the AHI is ≥5 events/hour.
To determine the severity of obstructive sleep apnea
Time Frame: 10 years
The severity of OSA is classified based on the AHI as follows: None/Minimal: AHI \< 5 per hour, Mild: AHI ≥ 5, but \< 15 per hour, Moderate: AHI ≥ 15, but \< 30 per hour, Severe: AHI ≥ 30 per hour.
Secondary Outcomes
- Vascular endothelial function(10 years)
- Insulin sensitivity(10 years)
- 24 hour mean arterial pressure(10 years)
- Body composition(10 years)