Non-pharmacological Interventions on Cognitive Functions in Older People With Mild Cognitive Impairment
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Mild Cognitive Impairment
- Sponsor
- Tzu-Ting Huang
- Enrollment
- 192
- Primary Endpoint
- Taiwan version of Prospectiv and Retrospective Memory Questionaire (PRMQ)
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
This project is proposed to be a three-year project. The purposes of this project are to develop and examine physical activity program, cognitive rehabilitation training, and new life-style (combination of exercise and cognitive) interventions on primary outcomes (cognitive function), and secondary outcomes (physical fitness, QOL and depression) among community-dwelling elderly adults with MCI.
Detailed Description
Aim. develop and examine physical activity program, cognitive rehabilitation training, and new life-style (combination of exercise and cognitive) interventions on primary outcomes (cognitive function), and secondary outcomes (physical fitness, QOL and depression) among community-dwelling elderly adults with MCI. Background. Mild cognitive impairment (MCI) is a common clinical syndrome that identifies people at high risk of developing dementia, and the prevalence range from 7.7 to 51.7%. Although treatments for MCI are currently unavailable, preliminary evidence has identified potential neuro-protective effects of exercise program and cognitive rehabilitation, which may lead to improved outcomes. However, the design and delivery of an appropriate program for people with MCI is challenging for having physical, psychological, cognitive, and social barriers. Design. A prospective randomized control trial. We developed a Physical activity stage-matched intervention (SMI) (1st year), cognitive rehabilitation (2nd year) and New lifestyle program
Investigators
Tzu-Ting Huang
Professor, School of Nursing
Chang Gung Memorial Hospital
Eligibility Criteria
Inclusion Criteria
- •had a subjective memory complaint
- •MMSE score\<16, 21 or 24, based on their years of education (illiterate, 6 or \>9 years, respectively, Yeh et al., 2000), but needed \>13 or objective memory impairment: AQ\>5 or at least one item of IADL dependence
- •able to carry out activities in daily life
Exclusion Criteria
- •using walking devices
- •depression or dementia diagnosis
Outcomes
Primary Outcomes
Taiwan version of Prospectiv and Retrospective Memory Questionaire (PRMQ)
Time Frame: 5min
There are 11 items and include general memory and prospective memory sections for analysis the type and frequency of memory problem in elders' daily live. Items are posed in likert scale ranges from 1 (never) to 5 (always). The total score may range from 11-55. A higher score indicates a higher level of memory impaired.
Mini-Mental State Examination
Time Frame: 8min
The participants' cognitive function was assessed by the Mini-Mental State Examination (cut point base for participants' levels of education).
The Alzheimer's Questionnaire
Time Frame: 2min
Malek-Ahmadi et al., (2012) a 21-item, informant-based dementia assessment designed for ease of use in a primary care setting.
Secondary Outcomes
- Depressive symptoms(3min)
- Mobility(10min)
- Quality of life(8min)