Comparison of Viola odorata and Budesonide in Reducing Airway Inflammation by Ultrasound and Cuff Leak Test
Phase 2
Recruiting
- Conditions
- tracheal inflammation.
- Registration Number
- IRCT20210516051314N1
- Lead Sponsor
- Esfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Age between 18 and 65 years old
intubation due to trauma
intubation atleast for 24 hours and during past 2 weeks
ongoing need for intubation
Exclusion Criteria
Failure to continue treatment for any reason, including the reluctance of the patient or the patient's caretaker
drug intolerance
tracheomalacia or any other airway disease
obesity hypoventilation syndrome or any other lung disease
inhaled or systemic corticosteroids usage in previous month
need for systemic corticosteroid administration in current addmision
hemodynamic instability
smoking 25 cigarettes per day or more
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Air column diameter between tracheal tube and tracheal wall. Timepoint: First and 7th day after intubation. Method of measurement: Ultrasound.;Tracheal wall thickness. Timepoint: First and 7th day after intubation. Method of measurement: Ultrasound.;Volume of air leak around tracheal tube. Timepoint: First and 7th day after intubation. Method of measurement: Expiratory tidal volume difference when the endotracheal tube cuff is full and empty and measured by a ventilator.
- Secondary Outcome Measures
Name Time Method