Transcranial Magnetic Treatment (TMS) in Unipolar Depression
- Conditions
- Unipolar Depression
- Registration Number
- NCT00186784
- Lead Sponsor
- St. Joseph's Healthcare Hamilton
- Brief Summary
Repetitive Transcranial Magnetic Stimulation (rTMS) can improve mood and decrease sadness in patients with depression.
In this study, the investigators seek to increase their understanding about how rTMS improves depression, and to determine which form of rTMS is most effective for depression, when used in combination with antidepressant medication.
- Detailed Description
Patients will be assigned for 4 treatment arms, receiving either left high frequency plus right low frequency, or left high frequency plus right sham, or left sham, plus right low frequency, or left sham plus right sham treatment. All subjects will receive treatments for 10 days and will be followed for another 4 weeks.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 21
- Major Depression
- No physical health problems
- History of Epilepsy
- Metal in the head/neck or skull
- Pacemaker
- Pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Hamilton Depression Rating Scale Pre TMS and post TMS Beck Depression Rating Scale pre TMS and post TMS
- Secondary Outcome Measures
Name Time Method Quantitive Electroencephalographic(QEEG)activity and measures of regional cerebral blood flow pre TMS and post TMS as well as post phase II, second set of TMS
Trial Locations
- Locations (1)
St.Joseph's Healthcare, rTMS Laboratory, Mood Disorders Program, 100 West Fifth Street
🇨🇦Hamilton, Ontario, Canada