NCT07398430尚未招募不适用
Metabolic Characteristics Analysis and Precise Prognostic Model Establishment for Patients With Acute Coronary Syndrome Complicated With Obstructive Sleep Apnea
Beijing Hospital0 个研究点目标入组 1,200 人开始时间: 2026年2月1日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 1,200
- 主要终点
- Incidence of Major Adverse Cardiovascular and Cerebrovascular Events (MACCE)
研究概览
简要总结
Obstructive sleep apnea (OSA) significantly increases the risk of cardiovascular events in patients with acute coronary syndrome (ACS), yet the underlying metabolic mechanisms remain unclear. This study aims to analyze the metabolic characteristics of ACS patients with OSA using metabolomics based on a prospective cohort. The study intends to construct an artificial intelligence-based risk stratification model to improve prognosis prediction and facilitate precision medicine for this population.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-85 years.
- •Diagnosed with ACS, including ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction, and unstable angina.
- •Willing to participate and sign the informed consent form.
排除标准
- •Cardiogenic shock or cardiac arrest.
- •Central sleep apnea or other types of sleep disordered breathing.
- •Previous or current treatment with continuous positive airway pressure.
- •Inability to complete polysomnography or invalid data.
- •Malignancy or life expectancy < 1 year.
结局指标
主要结局
Incidence of Major Adverse Cardiovascular and Cerebrovascular Events (MACCE)
时间窗: 12 Months
次要结局
未报告次要终点
研究者
WeiGong
Deputy Director
Beijing Hospital
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