Prevalence of and Prognostic Impact of Bronchiectasis in COPD Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Bronchiectasis
- Sponsor
- Assiut University
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Prevalence of Bronchiectasis in COPD
- Last Updated
- 6 years ago
Overview
Brief Summary
The identification of bronchiectasis in COPD has been defined as a different clinical COPD phenotype with greater symptomatic severity, more frequent chronic bronchial infection and exacerbations, and poor prognosis. A causal association has not yet been proven, but it is biologically plausible that COPD, and particularly the infective and exacerbator COPD phenotypes, could be the cause of bronchiectasis without any other known etiology, beyond any mere association or comorbidity.
Detailed Description
The relationship between bronchiectasis and COPD has generated several questions. Is there any real increased prevalence of bronchiectasis in patients with COPD? Does the presence of bronchiectasis have an impact on the clinical characteristics, prognosis, or response to treatment in COPD, to the extent that it can be considered a distinct clinical phenotype? Should bronchiectasis in patients with COPD be seen as merely a comorbidity, or as a consequence of the disease's natural history? Is there a causal relationship between COPD and bronchiectasis? If this is the case, what are the pathophysiological mechanisms responsible for this relationship? And, finally, what is the role of chronic bronchial infection and exacerbations in this relationship?
Investigators
Aliae AR Mohamed Hussein
Professor of Pulmonology
Assiut University
Eligibility Criteria
Inclusion Criteria
- •COPD patients based on GOLD 2019 criteria, stable or in exacerbation
Exclusion Criteria
- •acute pneumonia within 2 months
- •malignancy
- •congenital bronchiectasis ( immobile cilia syndrome, Kartagnar syndrome).
- •Pregnancy
Outcomes
Primary Outcomes
Prevalence of Bronchiectasis in COPD
Time Frame: 1 year
percentage of bronchiectasis diagnosed by CT chest in COPD patients
Secondary Outcomes
- impact of bronchiectasis on COPD intensive care admission(1 year)
- impact of bronchiectasis on COPD exacerbations(1 year)
- impact of bronchiectasis on COPD hospitalization(1 year)