Dietry Pattern and Lead Levels in Pregnancy

Completed

• Conditions: Lead Poisoning; Pregnancy Related; Dietary Habits
• Interventions: Other: None - observational

• Registration Number: NCT03408275
• Lead Sponsor: University of Bristol

Brief Summary

During pregnancy lead crosses the placenta freely and can have adverse effects on the fetus, with the potential for life-long impact on the child. Identification of dietary patterns and food groups in pregnancy in relation to measures of lead status could provide a more useful alternative to a nutrient-specific advice to minimise fetal exposure to lead during pregnancy. The aim is to evaluate whether dietary patterns and food groups are associated with blood lead concentrations in pregnancy.

Detailed Description

Whole blood samples were collected from pregnant women enrolled in the Avon Longitudinal Study of Parents and Children observational birth cohort study and were analysed for lead. Dietary pattern scores were derived from principal components analysis of a food frequency questionnaire. Associations of quartiles of dietary pattern scores, and of food groups categorised by frequency of consumption, with the likelihood of blood lead concentration (B-Pb) ≥5 µg/dl will be identified with adjusted logistic regression (n=2167).

Study Timeline

• Study Start: 1991-04-01
• Primary Completion: 1992-12-01
• Study Completion: 1992-12-01
• Status Verified: 2018-01
• Study First Submitted: 2018-01-16
• Study First Submitted QC: 2018-01-16
• Last Update Submitted: 2018-01-16
• Study First Posted: 2018-01-23
• Last Update Posted: 2018-01-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 2167

Inclusion Criteria

Enrolled in ALSPAC, pregnant -

Exclusion Criteria

Not enrolled in ALSPAC, not pregnant

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Pregnant women	None - observational	Pregnant women enrolled in ALSPAC

Primary Outcome Measures

Name	Time	Method
Blood lead concentration	During gestation	Blood lead concentration