Alzheimer's Disease Prevention Trial
- Conditions
- Alzheimer DiseaseMemory Disorders
- Registration Number
- NCT00000176
- Lead Sponsor
- National Institute on Aging (NIA)
- Brief Summary
This is a three-year study to determine if estrogens can prevent memory loss and Alzheimer's disease in women with a family history of Alzheimer's disease.
- Detailed Description
PREventing Postmenopausal memory loss and Alzheimer's with Replacement Estrogens (PREPARE) is a double-blind-placebo controlled trial to determine whether estrogen (or estrogen and progesterone) can delay the onset of memory loss or Alzheimer's Disease in elderly women with a family history of the disease.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- Not specified
- Healthy women 65 or older with a family history of memory problems not currently on estrogen.
- Significant neurological impairment
- Current estrogen use
- History of breast cancer
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (22)
New England Center for Headache
🇺🇸Stamford, Connecticut, United States
Johns Hopkins Bayview Medical Center
🇺🇸Baltimore, Maryland, United States
Neurology Group of Bergen County
🇺🇸Ridgewood, New Jersey, United States
University of Alabama
🇺🇸Birmingham, Alabama, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
Howard University
🇺🇸Washington, District of Columbia, United States
Lee Memorial Health System
🇺🇸Fort Myers, Florida, United States
Mayo Clinic Jacksonville
🇺🇸Jacksonville, Florida, United States
University of California, Irvine
🇺🇸Irvine, California, United States
North Broward Medical Center
🇺🇸Pompano Beach, Florida, United States
Columbia University
🇺🇸New York, New York, United States
Tallahassee Memorial Health Center
🇺🇸Tallahassee, Florida, United States
Wein Center
🇺🇸Miami Beach, Florida, United States
West Florida Regional Medical Center
🇺🇸Pensacola, Florida, United States
Cornell Medical Center, New York Presbyterian Medical Center
🇺🇸New York, New York, United States
Medical University of South Carolina
🇺🇸North Charleston, South Carolina, United States
Butler Hospital, Rhode Island Hospital
🇺🇸Providence, Rhode Island, United States
New York United Hospital Medical Center
🇺🇸Port Chester, New York, United States
St. Mary's Medical Center
🇺🇸West Palm Beach, Florida, United States
Clinical Pharmaceutical Trials
🇺🇸Tulsa, Oklahoma, United States
Burke Medical Research Institute
🇺🇸White Plains, New York, United States
Eastern Virginia Medical School
🇺🇸Norfolk, Virginia, United States