Comparative Assessment of High Sensitive CRP and Carotid Stiffness Between Patients With and Without Coronary Slow Flow
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- High Sensitive C-reactive protein
研究概览
简要总结
This study aims to compare the levels of high-sensitivity C-reactive protein (hs-CRP) and carotid artery stiffness between patients with coronary slow flow phenomenon (CSFP) and those with normal coronary flow.
详细描述
The coronary slow flow phenomenon (CSFP) is characterized by delayed opacification of the coronary arteries during angiography in the absence of significant epicardial coronary artery disease.
Hypothesis
High-sensitivity C-reactive protein (hs-CRP) is a well-established biomarker of systemic inflammation and has been associated with various cardiovascular conditions. Elevated hs-CRP levels have been observed in patients with CSFP, suggesting an inflammatory component in its pathogenesis. This marker not only predicts future cardiovascular events but may also reflect ongoing vascular inflammation in patients with angiographically normal coronary arteries.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years old.
- •Both sexes.
- •Patients undergo coronary angiography for evaluation of chest pain or suspected ischemia.
排除标准
- •Pregnant or breastfeeding women.
- •History of cardiovascular events such as myocardial infarction or stroke.
- •Diagnosed autoimmune disorders, chronic hepatic or renal diseases.
- •Current or recent infections.
- •History of malignancy.
- •Patients taking medications known to affect inflammatory markers (e.g., corticosteroids or immunosuppressants).
结局指标
主要结局
High Sensitive C-reactive protein
时间窗: 24 hours post-angiography
High Sensitive C-reactive protein will be measured.
次要结局
- Stiffness indices(24 hours post-angiography)
研究者
Remon Saleh Adly
Lecturer of Cardiovascular, Faculty of Medicine, Sohag University, Sohag, Egypt.
Sohag University